The best defense against emerging variant strains of COVID-19 is getting as many people vaccinated as quickly as possible, top U.S. infectious disease doctor Anthony Fauci said on Monday.

He told a media briefing that while it was reasonable to think about studying the efficacy of Pfizer’s and Moderna’s vaccines as a one-dose regimen in light of supply constraints, such a study would take months to complete and thus likely make its conclusions moot.

Fauci continued to encourage people get two doses of the vaccine.

The optimal ā€œapproach would be to continue with getting as many people on their first dose as possible but also making sure that people on time get their second dose,ā€ Fauci said.

CDC Director Rochelle Walensky said on the call that she advises people to continue wearing masks and that states not relax mask-wearing rules. The Biden Administration asked Americans to wear masks for its first hundred days, a period she noted is ongoing.

(Reporting by Carl O’Donnell, Editing by Franklin Paul and Dan Grebler)