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Li Gan

researcher

Li Gan

investigadora (ORCID 0000-0002-5136-7158)

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About Li Gan

Li Gan es una neurocientífica y profesora en Weill Cornell Medical College. Es conocida por su descubrimiento de la acetilación de la proteína tau patogénica en las tauopatías y los mecanismos de disfunción de la microglía en la neurodegeneración.

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Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy.An 8‐week, open‐label, dose‐finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations Microglial microRNAs mediate sex-specific responses to tau pathology Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy A MAC2-positive progenitor-like microglial population is resistant to CSF1R inhibition in adult mouse brain Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy Weill Cornell Medicine

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