Huntington's disease.
rare neurodegenerative disorder of the central nervous system characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia

UniQure shares plunge after Huntington's therapy fails trial
UniQure lost about $1 billion in market value as shares fell 37-40% after four-year Huntington's data showed 44% slowing that missed statistical significance.
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About Huntington's disease
Huntington's or Huntington disease (HD), also known as Huntington's chorea, is a fatal neurodegenerative disease that is usually inherited. It typically presents as a triad of progressive psychiatric, cognitive, and motor symptoms. The earliest symptoms are often subtle problems with mood or mental/psychiatric abilities, which precede the motor symptoms for many people. The definitive physical symptoms, including a general lack of coordination and an unsteady gait, eventually follow. Over time, the basal ganglia region of the brain gradually becomes damaged.
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