• Latest
  • Trending
  • All
  • News
  • Business
  • Lifestyle
Bar-Ilan University’s Nanoparticles Revitalize Exhausted NK Cells To Fight Cancer‌
‌

Bar-Ilan University’s Nanoparticles Revitalize Exhausted NK Cells To Fight Cancer‌ ‌

August 30, 2024
MICHAEL GLASSNER: Socialist Fantasy, Urban Decay: What New York’s Mayoral Race Means For America

MICHAEL GLASSNER: Socialist Fantasy, Urban Decay: What New York’s Mayoral Race Means For America

July 6, 2025
CHRIS JOHNSON And AIDEN BUZZETTI: The Left’s Prophesy Of Environmental Apocalypse Demands Revival On The Right

CHRIS JOHNSON And AIDEN BUZZETTI: The Left’s Prophesy Of Environmental Apocalypse Demands Revival On The Right

July 6, 2025
STEVE MILLOY: President Trump: Terminate The Green New Scam Now

STEVE MILLOY: President Trump: Terminate The Green New Scam Now

July 6, 2025
DAVID BLACKMON: The OBBBA Resets The Energy Policy Playing Field

DAVID BLACKMON: The OBBBA Resets The Energy Policy Playing Field

July 5, 2025
MANDY GUNASEKARA: Puerto Rico Saw The Light — Why Won’t Honolulu?

MANDY GUNASEKARA: Puerto Rico Saw The Light — Why Won’t Honolulu?

July 5, 2025
MATT MOWERS: After NATO Summit, Europe’s Free Ride Is On The Line

MATT MOWERS: After NATO Summit, Europe’s Free Ride Is On The Line

July 5, 2025
JENNY BETH MARTIN: A Socialist Victory – And A Warning For America’s 249th Birthday

JENNY BETH MARTIN: A Socialist Victory – And A Warning For America’s 249th Birthday

July 4, 2025
Trump Says Friday Is Elon Musk’s ‘Last Day, but Not Really’

Musk Continues Push For America Party

July 4, 2025
Trump Signs ‘Big, Beautiful Bill’ Into Law

Trump Signs ‘Big, Beautiful Bill’ Into Law

July 4, 2025
Lee Greenwood on ‘God Bless the USA’ Legacy: ‘That’s Where Patriotism Starts’

Lee Greenwood on ‘God Bless the USA’ Legacy: ‘That’s Where Patriotism Starts’

July 4, 2025
Trump Seeking Military Costumes for Parade

Trump Lambasts Dems Who Voted Against ‘Big, Beautiful Bill’

July 4, 2025
WILL SELLERS: Misunderstanding The Road To Independence

WILL SELLERS: Misunderstanding The Road To Independence

July 4, 2025
  • Donald Trump
  • State of the Union
  • Elon Musk
  • Tariffs
  • Congress
  • Faith
  • Immigration
Sunday, July 6, 2025
  • Login
IJR
  • Politics
  • US News
  • Commentary
  • World News
  • Faith
  • Latest Polls
No Result
View All Result
IJR
No Result
View All Result
Home FaithTap

Bar-Ilan University’s Nanoparticles Revitalize Exhausted NK Cells To Fight Cancer‌ ‌

by Zenger
August 30, 2024 at 2:41 pm
in FaithTap, News, Wire
245 7
0
Bar-Ilan University’s Nanoparticles Revitalize Exhausted NK Cells To Fight Cancer‌
‌
491
SHARES
1.4k
VIEWS
Share on FacebookShare on Twitter



<p>Prof. Mira Barda-Saad from the Goodman Faculty of Life Sciences, Bar Ilan University. BIU </p>
<p>“></p>
<p>It’s not just our minds and bodies that get exhausted when battling cancer, it’s also the natural killer (NK) cells of our bodies – a key component of the immune system – that get fatigued and lose function when they have to keep fighting the disease.</p>
<p>Now, a new study at Bar-Ilan University offers a novel method to rejuvenate NK cells using nanoparticles, restoring their vitality to give them the strength to keep fighting cancer cells.</p>
<p>Cancer is the second leading cause of death in the United States, after heart disease. In 2024, the American Cancer Society estimates that there will be two million new cancer cases in the country – around 5,480 new diagnoses every day.</p>
<p>NK cells are a key component of the immune system, and are crucial for identifying and destroying cancerous and viral cells.</p>
<p>In recent years, doctors have begun working with immunotherapeutic strategies, such as the Chimeric Antigen Receptor (CAR) approach, to extract patient cells, modify them genetically in a laboratory to enhance their ability to combat cancer cells, and then reintroduce them into the body.</p>
<p>New research has shown, however, that the lymphocytes – either T cells or NK cells, including the engineered NK cells – can become fatigued from continuously battling tumors and subsequently lose their function.</p>
<p>To bypass this process, Prof. Mira Barda-Saad and a team of researchers at the Goodman Faculty of Life Sciences identified the underlying causes of NK cell dysfunction and developed a novel solution.</p>
<p>They use nanoparticles that target and silence negative regulators and restore NK cell activity directly within the patient’s body, bypassing the need for cell extraction and genetic modification.</p>
<h2 class=Prof. Mira Barda-Saad from the Goodman Faculty of Life Sciences, Bar Ilan University. BIU Prof. Mira Barda-Saad from the Goodman Faculty of Life Sciences, Bar Ilan University. BIU 

According to the researchers, NK cell dysfunction occurs in two ways. The first is during the “training process” in the immune system. If this process is disrupted and they receive inappropriate signals, it can lead to “anergic” NK cells that don’t function correctly.

The second is in the tumor microenvironment. When NK cells encounter a tumor, they are constantly stimulated. If this stimulation is excessive and prolonged, it can lead to exhaustion where the NK cells become less effective at fighting cancer.

Barda-Saad’s group analyzed anergic and exhausted NK cells from both their training phase and tumor microenvironment, and found that they are similarly dysfunctional. They identified two key factors contributing to this dysfunction: the enzyme DGK alpha and the transcription factor Egr2.

“Experiments in three-dimensional tissue culture and in-vivo mice models have shown that nanoparticles, acting as a platform for drug delivery, can reprogram the dysfunctional natural killer cell population,” said Barda-Saad.  

“After the research group introduced nanoparticles that silence the two negative regulators, the killer cells returned to their normal function and efficiently killed cancer cells.”

These promising findings, obtained in animal models bearing aggressive pancreatic cancer, could pave the way for the development of effective treatments against solid tumors using an immunotherapeutic strategy, offering hope to patients and professionals in the field.

     

              Produced in association with ISRAEL21c

              Tags: U.S. NewsZenger
              Share196Tweet123
              Zenger

              Zenger

              Advertisements

              Top Stories June 10th
              Top Stories June 7th
              Top Stories June 6th
              Top Stories June 3rd
              Top Stories May 30th
              Top Stories May 29th
              Top Stories May 24th
              Top Stories May 23rd
              Top Stories May 21st
              Top Stories May 17th

              Join Over 6M Subscribers

              We’re organizing an online community to elevate trusted voices on all sides so that you can be fully informed.





              IJR

                  Copyright © 2024 IJR

              Trusted Voices On All Sides

              • About Us
              • GDPR Privacy Policy
              • Terms of Service
              • Editorial Standards & Corrections Policy
              • Subscribe to IJR

              Follow Us

              Welcome Back!

              Login to your account below

              Forgotten Password?

              Retrieve your password

              Please enter your username or email address to reset your password.

              Log In
              No Result
              View All Result
              • Politics
              • US News
              • Commentary
              • World News
              • Faith
              • Latest Polls

                  Copyright © 2024 IJR

              Top Stories June 10th Top Stories June 7th Top Stories June 6th Top Stories June 3rd Top Stories May 30th Top Stories May 29th Top Stories May 24th Top Stories May 23rd Top Stories May 21st Top Stories May 17th