Victoria Azarenka and Bob Bryan defeated Katarina Srebotnik and Nenad Zimonjić in the final, 6–2, 7–6(7–4) to win the mixed doubles tennis title at the 2008 French Open.
Nathalie Dechy and Andy Ram were the defending champions, but lost in the first round to Dominika Cibulková and Gaël Monfils.
Draw
Key