Albuquerque (Portuguese pronunciation: [alβuˈkɛɾkɨ]) is a common Portuguese surname, which may refer to:
Afonso de Albuquerque (1453–1515), a Portuguese fidalgo and naval general officer
Benedito Francisco de Albuquerque (born 1928), Brazilian Roman Catholic bishop
Cássio Albuquerque dos Anjos (born 1980), a Brazilian goalkeeper
Catarina de Albuquerque (1970–2025), Portuguese lawyer and human rights activist
Felipe Albuquerque (born 1999), Brazilian footballer
Filipe Albuquerque (born 1985), Portuguese race car driver
Hermenegildo Portocarrero, Baron of Forte de Coimbra (1818–1893), Brazilian nobleman and military officer, marshal in the Brazilian Army
João Pessoa Cavalcânti de Albuquerque (1878–1930), the governor of Paraíba, Brazil between 1928 and 1930
Joaquim Arcoverde de Albuquerque Cavalcanti (1850–1930), Brazilian Roman Catholic prelate, the first cardinal to be born in the Americas
Joaquim Augusto Mouzinho de Albuquerque (1855–1902), Portuguese soldier
João Albuquerque (born 1986), Portuguese politician
José Albuquerque (born 1975), Brazilian boxer
José Paulino de Almeida e Albuquerque (?–1830), Brazilian military and politician
Lita Albuquerque, US environmental artist, painter and sculptor
Luís da Silva Mouzinho de Albuquerque (1792–1846), Portuguese military officer, engineer, poet, scientist and politician
Marcos Venâncio de Albuquerque (born 1980), Brazilian footballer
Mike de Albuquerque (born 1947), English musician
Oscar Albuquerque (born 1954), former Canadian soccer midfielder
Renato de Albuquerque, Brazilian civil engineer and entrepreneur in the construction and real state businesses
Roberto Albuquerque (born 1993), American soccer player
Glasner da Silva Albuquerque (born 1980), known as Esquerdinha Brazilian footballer