Plot
Afghanistan Marine veteran Will Sharp, desperately needing money for his wife Amy's surgery, reaches out to Danny, his adoptive brother and life-long criminal. He is talked into being the getaway driver for a $32 million bank heist. Though initially hesitant, Will agrees after Danny reaffirms that he is doing it for his wife, Amy.
The plan nearly succeeds until Officer Zach, who enters the bank to ask out a bank teller, discovers the situation and is held hostage. A shootout then occurs between one of the heist members and Zach's partner Officer Mark. The Special Investigation Section (SIS) of the LAPD arrives, killing or arresting most of the crew except for Will and Danny, who retreat toward the garage.
Zach attempts to escape, and during a scuffle is accidentally shot by Will. Leaving him behind, the brothers attempt to exit through the back of the building but find it surrounded by police. They then hijack an ambulance with EMT Cam Thompson, who is treating the injured Zach, on board. After a chase that leads them into an alleyway, Cam makes a desperate attempt to escape using a fire extinguisher but is quickly recaptured by Danny.
SIS Captain Monroe arrives on the scene and deploys helicopters to chase after the ambulance. Cam gets Danny to help her use a defibrillator and Will to transfer some of his blood to Zach, much to his confusion and frustration. Danny then calls Papi, one of his father's criminal friends, for help losing the police in exchange for $8 million.
When Cam stops Danny from shooting Mark, who has been chasing them, he threatens to throw her off the ambulance. The police are forced to retreat when it is discovered that Monroe's dog is inside Mark's police vehicle. FBI Agent Anson Clark, a former friend of Danny's, is put on the case. Zach begins to bleed out; Cam calls her surgeon ex-boyfriend, and with Will's assistance, begins to perform surgery on him.
Despite her inexperience and his spleen rupturing, Cam successfully performs the surgery. After, she tries to convince Will to stop Danny, to no avail. Monroe, unaware of the surgery's success, moves forward with the operation, preparing to snipe Will and Danny without negotiating for Cam's life. Clark calls Cam and tells her to get down.
Cam, not wanting them all to die, alerts Will and Danny about the snipers. Danny, fed up with her, decides to shoot her, but Will intervenes, causing the brothers to fight about their predicament. They later partially reconcile and listen to music together to ease the tension.
In the Los Angeles River, helicopters chase the ambulance as Danny shoots at them. Will and Danny then drive on the opposite lane of the interstate, creating multiple accidents. On Papi's orders, his son Roberto sends multiple ambulance decoys to distract the police and drives an ambulance towards a police roadblock after filling it with C-4 explosives. Papi deploys a minigun on a separate car to cause additional damage, wounding Monroe in the crossfire.
Mark chases down Roberto and fatally shoots him after a scuffle, leaving Papi angry and distraught. Will and Danny escape to Papi's hideout. He demands the brothers leave Zach and Cam with them to deal with; Will refuses to cooperate and teams up with Danny to kill Papi and his crew.
In the chaos, Cam accidentally shoots Will with Zach's gun. Danny takes the ambulance to a hospital and discovers the gun. He is enraged when Cam reveals that she was the one who shot Will. Danny vows to kill her along with himself on live television before confronting the police.
Left with no other choice, Will shoots Danny in the back, who apologizes to him before succumbing to his injuries. The police arrest a critically injured Will, however they were willing to let him bleed out, and only take him inside for surgery after Cam guilts Zach's partner Mark into helping. Cam secretly gives some of the heist money to Amy for her surgery, and Zach, when questioned by the police about his injuries, tells them that Will saved his life.