Andreas Wagner

Andreas Wagner (born 26 January 1967) is an Austrian/US evolutionary biologist and professor at the University of Zürich, Switzerland. He is known for his work on the role of robustness and innovation in biological evolution. Wagner is professor and chairman at the Department of Evolutionary Biology and Environmental Studies at the University of Zürich. Biography Wagner studied biology at the University of Vienna. He received his Ph.D. at Yale University, Department of Biology in 1995. He also holds a M. Phil. from Yale. From 1995 to 1996 he was a fellow at the Institute for Advanced Study Berlin, Germany. From 1998 to 2002 he was assistant professor at the University of New Mexico, Department of Biology and from 2002 to 2012 associate professor (with tenure) at the University of New Mexico, Department of Biology. He was appointed professor at the University of Zürich, Institute of Biochemistry in 2006. In 2011, he joined the Department of Evolutionary Biology and Environmental Studies at the University of Zürich. Since 2016, he is chairman of this department. Since 1999, he is also external professor at the Santa Fe Institute, New Mexico, USA. Scientific contribution Wagner's work revolves around the robustness of biological systems, and about their ability to innovate, that is, to create novel organisms and traits that help them survive and reproduce. Robustness is the ability of a biological system to withstand perturbations, such as DNA mutations and environmental change. Early in his career Wagner developed a widely used mathematical model for gene regulatory circuits, (Wagner's gene network model) and used this model to demonstrate that natural selection can increase the robustness of such circuits to DNA mutations. Experimental work in Wagner's Zürich laboratory showed that proteins can evolve robustness to perturbations. One source of robustness to mutations are redundant duplicate genes. Natural selection can maintain their redundancy and the ensuing robustness. However, more important than redundancy, Wagner has argued, is the “distributed robustness” of complex biological systems, which arises from the cooperation of multiple different parts, such as proteins in a regulatory network. Wagner showed that robustness can accelerate innovation in biological evolution, because it helps organisms tolerate otherwise deleterious mutations that can help create new and useful traits.