Antonia Tryphaena also known as Tryphaena of Thrace or Tryphaena (Greek: Ἀντωνία Τρύφαινα or Τρυφαίνη, 10 BC – 55 AD) was a Pontian Princess and a Roman Client Queen of Thrace. She co-ruled with her son Rhoemetalces II. Origins, family and early life Tryphaena was the only known daughter and the youngest child of Roman client rulers Polemon Pythodoros and Pythodorida of Pontus. Her elder brothers were Zenon, also known as Artaxias III, who became Roman client king of Armenia and Polemon II of Pontus, who would succeed her mother and became the last Roman client ruler of Pontus. She was of Anatolian Greek and Roman heritage. Her paternal grandfather was Zenon, a prominent orator and aristocrat, who had been an ally to Mark Antony. Her maternal grandparents were the wealthy Greek friends of the late Roman Triumvir Pompey Pythodoros of Tralles, and Antonia.

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Antonia Tryphaena also known as Tryphaena of Thrace or Tryphaena (Greek: Ἀντωνία Τρύφαινα or Τρυφαίνη, 10 BC – 55 AD) was a Pontian Princess and a Roman Client Queen of Thrace. She co-ruled with her son Rhoemetalces II.