Barrio is a Spanish surname. Notable people with the surname include:
Artur Barrio (born 1945), Brazilian artist
Diego Martínez Barrio (1882–1965), Spanish politician
Francisco Barrio (1950–2025), Mexican politician
Paquita la del Barrio (1947–2025), Mexican singer, songwriter, and actress
Ramon Del Barrio (born 1964), American performer, choreographer, dancer and singer
Sonia Barrio (born 1969), Spanish field hockey player
Víctor Barrio (1987–2016), Spanish bullfighter