Recurring
Juri Henley-Cohn as Luke Hayden – One of Winter's team and an Orchestra fugitive. Hayden later becomes disillusioned with the mission to protect Bo after the deaths of four of the ten team members, and ultimately feels he could not make the necessary sacrifices. He abandons the team, and is arrested by the FBI shortly after. Ferrell turns Hayden to apparently give up Winter's command center in New York, only for Ferrell's team to find it deserted.
Richard Hollis as Robert Gilman – One of Winter's team and an Orchestra fugitive.
Katie McClellan as Lilah Leeds – One of Winter's team and an Orchestra fugitive. She is a technology specialist, and was on the team that developed Orchestra's prototype telepathic tracking computer.
Kerry Condon as Dr. Zoe Boyle – Orchestra's head of research and Winter's replacement, Zoe is Skouras's head researcher and loyal confidant at Orchestra, who runs the research program following Winter's departure – working to continue experiments with the other talented telepaths at the facility. Zoe helped Winter raise Bo, and cares about her very deeply. After Winter's departure, Zoe wants Bo returned home to Orchestra (primarily due to the possibility that Bo's health could degrade due to her abilities), seeing her as one of a kind and vulnerable in the outside world. Nevertheless, Bo remains the common ground that allows Winter and Zoe to trust each other - she is aware that Winter took Bo as the military would use her as a weapon, and also isn't comfortable with Skouras's excessive experimentation methods. In no position to challenge his authority, Zoe secretly acts as Winter's mole inside the Orchestra Campus, until she is exposed to Skouras by Dani, another test subject. Skouras has Dani mentally erase all of Zoe's memories of Bo and Orchestra.
Arian Moayed as Corey – A technology specialist working at Orchestra. He is completely loyal to Skouras.
Erik LaRay Harvey as Marcus Krakauer – A mercenary on loan from the CIA, and a tracker not on the FBI's radar, who is rumored to be psychotic. He is hired by Skouras as an operative to track down Bo and Tate.
Nick Tarabay as Niko Zepeda – Skouras's henchman working at Orchestra.
Peter McRobbie as FBI Director Lofton – The Director of the FBI and Ferrell's superior. He is one of the government administration members working with Skouras and Orchestra. He acts as a liaison with Skouras to the government, while also giving Ferrell permission to use federal orders and other ample resources for the investigation to locate and recover Bo. Later, Ferrell informs Lofton she has quit the Tate case but will still remain with the FBI.
Trieste Kelly Dunn as FBI Special Agent Elizabeth Ferrell – The FBI agent in charge of full-fledged manhunt launched to recapture escaped death row inmate William Tate, Ferrell is solicited by the Director of the FBI to help and work with Skouras and Orchestra to track down Tate and Bo. Skouras emphasizes repeatedly that Bo is his top priority, assuring her that Bo's safety is his main concern, but she can tell he's not being entirely honest with her. Ferrell issues a nationwide Amber alert, broadcasting photos of Bo and Tate on every news channel over Skouras's repeated objections. Originally adopting traditional FBI methods to apprehend Tate, whom she sees as a very dangerous fugitive, and "rescue" Bo, whom she sees as an endangered minor, Ferrell steadily begins to understand what Bo is capable of, and also begins realizing there is more behind the manhunt than originally assumed. According to her background, she has a young daughter named Sasha. After Tate and Bo save Ferrell and her daughter from a subway bombing, Ferrell finally accepts Tate's innocence and abandons her pursuit.
Matthew Rauch as FBI Agent Martin – One of Ferrell's two best agents.
Ato Essandoh as FBI Agent Garner – One of Ferrell's two best agents.
Rob Morgan as Joshua Carpenter – An Orchestra test subject, Joshua was a promising telepath capable of matter manipulation, who has been with Orchestra almost three years, and was one of Skouras's most talented subjects. His experimentation had left him fully weaponized as an active telepathic assassin. Skouras sent his new weapon on a field assignment – to track down Bo and locate and neutralize Orchestra's unknown insider leak (Zoe Boyle). During the confrontation, however, Bo attacked and left him incapacitated as he is mentally erasing a blogger's mind. Left in a coma with no possibility to recover, Skouras encouraged Shawn, his friend and fellow test subject, to "help" Joshua by putting him out of his misery, as well as showing his own strength. Shawn reluctantly kills his friend at Skouras' request.
Owen Campbell as Shawn – An Orchestra test subject, Shawn is a promising telepath, not as powerful as Bo. He has suffered severe behavioral and emotional problems due to his ability, although Orchestra has worked hard to harness his gifts. Skouras orders Shawn's rapid development to satisfy Orchestra's military superiors, over Zoe's objections that Shawn's control over his abilities was fragile, and the risk of instability was too great. Skouras encourages Shawn to accept and embrace his gifts, and manipulates him into becoming an active telepathic assassin. Shawn reluctantly kills Joshua, his friend and fellow test subject now comatose, with his powers to show his strength.
Mia Vallet as Dani – An extremely powerful telepath who was inadvertently discovered by Orchestra (when her powers are detected by Skouras's telepathic tracking computer), Dani is the most powerful telepath Orchestra has come across since Bo, but she is untrusting and fiercely independent when she quickly realizes the extent of her power. Skouras meets with Dani and eventually convinces her to be taken to Orchestra, and accepts Skouras' training to make her abilities stronger. Skouras sees Dani as his next masterpiece – intending to turn her into his new weapon. Dani discovers Zoe is the Orchestra mole, and threatens to out her to Skouras if she interferes with Skouras' plan. According to her background, she is a homeless runaway with no family or friends, previously involved in foster care and group homes. Her earliest memory of having an ability was when she was five, while at school, she started telekinetically moving pencils, but her parents thought she was lying. When she was twelve, they became afraid of their daughter when they thought Dani killed her brother in an angry rage over her stolen diary.
