Blandford is a surname. Notable people with the surname include:
Don Blandford, longtime Kentucky state legislator
George Fielding Blandford (1829–1911), English physician and psychiatrist
Mark Blandford (entrepreneur) (born 1957), British entrepreneur
Mark Harden Blandford (1826–1902), American soldier, attorney, politician and judge
Roger Blandford (born 1949), astronomer and astrophysicist
Walter F. H. Blandford, entomologist