Recurring
Johnny Whitworth as Markos (seasons 1 & 5), a mysterious man connected to Jane's past. He was killed by an unknown sniper – later revealed to be Oscar – in Jane's safe house. He was a member of the terrorist organization Sandstorm, but grew disenchanted with their treatment of Jane. He reappears as a hallucination caused by Jane's ZIP poisoning in the series finale.
Jordana Spiro as Sarah Weller (seasons 1 & 5), Kurt's sister. Sarah tries to heal Weller's lingering emotional trauma from Taylor Shaw's disappearance, and to repair the broken relationship between Kurt and their terminally ill father. She was in love with Kurt's co-worker and friend, Edgar Reade, until he broke up with her to protect her and her son. She later moves to Portland, Oregon, with her son. She returns in the series finale, having dinner with the team and their family and friends.
Logan Schuyler Smith as Sawyer (seasons 1 & 5), Sarah's son and Kurt's nephew. He moves to Portland, Oregon, with his mother shortly after her breakup with Reade, but he appears in the series finale, having dinner with the team and their family and friends.
Michael Gaston as Thomas "Tom" Carter (seasons 1 & 5), CIA deputy director, who is connected, with Mayfair, to the clandestine Operation: Daylight. He is very interested in Jane because he is afraid that her tattoos could reveal Daylight's existence. He is killed by Oscar, while trying to interrogate Jane. He reappears as a hallucination because of Jane's ZIP poisoning in the series finale.
Joe Dinicol as David Wagner (seasons 1, 3, & 5), Patterson's boyfriend. Patterson broke up with him after being reprimanded for sharing the tattoos with David. He is killed by a Russian agent for investigating an undercover spy ring, but reappears in Patterson's coma dream in season 3 and as a hallucination caused by Jane's ZIP poisoning in the series finale. His character was modeled after David Kwong, who works as a puzzle consultant for the show.
Jay O. Sanders as Bill Weller (seasons 1 & 5), Kurt and Sarah's father. He was accused of kidnapping and killing Taylor Shaw because he lied about his alibi. This destroyed his life and marriage and ended his relationship with his son. He is terminally ill with lung cancer. His admission that he attempted suicide the night of Taylor's disappearance finally earns back Kurt's trust. However, he confirms on his deathbed he really did kill Taylor Shaw, although he maintains it was accidental. He reappears in season 5 as a hallucination of Weller's.
François Arnaud as Oscar (seasons 1 & 5), a mysterious man connected to Jane's past. Partial flashbacks reveal that Oscar is Jane's ex-boyfriend. They planned to marry, but Jane broke off the engagement. Although he appears to be Jane's ally against some of the radical elements of Sandstorm, the terrorist organization that gave Jane her tattoos, he lied to her about her past identity as Taylor Shaw, and seemingly harmless tests were actually part of a complex scheme to frame Mayfair for murder and corruption. When he attempts to inject Jane with a new dose of drugs to erase her memory again, Jane tries to arrest him. She accidentally stabs him in the heart with a scythe when they fight in a burning barn. He reappears in season 5 in hallucinations, seen by Weller and Jane.
Lou Diamond Phillips as Saúl Guerrero (seasons 1 & 5), a notorious gang leader and Number Two on the FBI Ten Most Wanted Fugitives list, he is connected to Operation: Daylight, serving as the "official" source of the information Mayfair gained from the program. He was killed on Tom Carter's orders while in prison. He later reappears as a hallucination as a result of Jane's ZIP poisoning in the series finale.
Trieste Kelly Dunn as Allie Knight, a former FBI agent, now a U.S. Marshal and FBI WITSEC liaison. She is Kurt's ex-girlfriend; she attempts to restart their relationship. She and Kurt have a daughter, Bethany.
John Hodgman as Jonas Fischer (seasons 1 & 5), a chief inspector in the FBI Office of Professional Responsibility who maneuvers to replace Mayfair. He is exposed as a Russian asset. Jane kills him when he tries to frame her as the mole in his place. He reappears in flashbacks and as a hallucination as a result of Jane's ZIP poisoning in the series finale.
Ajay Naidu as Sho Akhtar (seasons 1 & 3–5), an occasional enemy and ally of the team. He is killed by Madeline's team in season 5 after giving Weller's team the blueprints to the CIA black site where Rich Dotcom is being held. He later reappears as a hallucination as a result of Jane's ZIP poisoning in the series finale.
Josh Dean as Boston Arliss Crab, an art restorer who is Rich Dotcom's ex-boyfriend and partner in crime .
Sarita Choudhury as Sofia Varma (seasons 1 & 5), deputy White House political director, who was connected with Mayfair to Operation: Daylight and was Mayfair's girlfriend. She was reported to have killed herself, affecting Mayfair deeply. In fact, she faked her death and went into hiding, supposedly to escape unknown pursuers. She is really part of the conspiracy behind Jane's tattoos. She participates in a Oscar's plot to frame Mayfair for murder. She reappears as a hallucination as a result of Jane's ZIP poisoning in the series finale.
Eisa Davis as Donna Hollaran/Alexandra Harrison (season 1), a sales clerk who becomes romantically involved with Mayfair. She is stabbed to death in her hotel room as a warning to Mayfair to stay away from Carter's death. The investigation that follows implicates Mayfair as the killer–according to evidence Oscar manipulated Jane into planting in Mayfair's office–and reveals that Alexandra is a disgraced private-investigator-turned-fixer who is under federal investigation.
Aaron Abrams as Matthew Weitz, an ambitious assistant U.S. attorney secretly investigating FBI corruption and specifically targeting Mayfair on the grounds of misconduct, with Zapata's reluctant cooperation. He later becomes a congressman, and in season 4, he is appointed to succeed Eleanor Hirst as director of the FBI, becoming the third director in the series. In season 5, after Madeline Burke takes over federal law enforcement and frames the team for corruption, terrorism, and treason, he works with analysts Briana Ross and Afreen Iqbal in a secret alliance to clear the team and take her down. After Madeline murders Briana, he is forced to scale back his efforts, but eventually, he and Afreen are able to destroy the blackmail material she holds against her connections. After the team is captured and Patterson reveals Madeline's attempt to frame him for her crimes, he flees, but he later returns with loyal agents. They and the team engage in a shootout with the Dabbur Zhan mercenaries in an attempt to retake the FBI. Despite the successful coup, Weitz is critically wounded in the crossfire and dies in the FBI headquarters. He later reappears as a hallucination as a result of Jane's ZIP poisoning in the series finale.
Dylan Baker as Sam Pellington (seasons 1–3 & 5), the initial director of the FBI in the series. He is killed by Shepherd during Sandstorm's attack on the FBI in season 2, and reappears in Patterson's coma dream in season 3 and as a hallucination as a result of Jane's ZIP poisoning in the series finale.
Tom Lipinski as Cade (seasons 1–3 & 5), an openly gay operative of Sandstorm. He betrays the organization in season 2 after realizing that Shepherd has become the very thing she despises and becomes Nas Kamal's informant. After cooperating with the FBI, Cade is granted immunity and disappears for several years, eventually settling down with a husband and an adopted son. He is captured by the CIA and put into a black site, but later escapes after the plane transporting him crashes. Despite his cooperation, the FBI is unable to keep him from the CIA. Upon learning this, Cade takes Zapata hostage and goads Jane into killing him, to spare himself from any more imprisonment or torture. He reappears as a hallucination due to Jane's ZIP poisoning in the series finale.
Chad Donella as Jake Keaton (seasons 2–5), deputy director of the CIA, who succeeds Tom Carter after the latter's death. He tortured Jane for information after the FBI turned her over to the CIA. He occasionally crosses paths with Weller's team during covert missions. He becomes more sympathetic to their agenda after they help him to save his daughter. In season 3, he becomes Zapata's superior when she joins the CIA. In season 4, he is left in a coma on life support after an attack that also reveals that he was acting as Zapata's handler during an undercover assignment. That assignment involved her supposedly being fired from the CIA. He is promoted and reassigned against his will at the end of the season as part of Madeline Burke's plan to take control of the FBI. During season 5, Keaton allies with Alison Knight and Boston Arliss Crab to help the team prove their innocence, but he is forced to betray them after Madeline threatens his family. He tries to turn on Madeline when she comes to arrest Zapata, only to be shot down and killed by her men. He reappears as a hallucination as a result of Jane's ZIP poisoning in the series finale.
Jonathan Patrick Moore as Oliver Kind (seasons 2 & 5), a water conservation specialist who befriended Jane. They briefly date during season 2 until he breaks up with her after the two become involved in a kidnapping-extortion plot linked to his father. He is unable to deal with her high-octane lifestyle. He reappears as a hallucination due to Jane's ZIP poisoning in the series finale.
Jefferson White as Parker Lewis (seasons 2 & 5), a loyal Sandstorm operative. After Jane and Roman betray the organization and leave, he takes over as Shepherd's second-in-command until his death in a shootout with the FBI near the end of season 2. He later reappears as a hallucination as a result of Jane's ZIP poisoning in the series finale.
Li Jun Li as Karen Sun (season 2), a psychiatrist whom Nas Kamal brought in to evaluate Roman. After Borden's exposure as a Sandstorm mole, she assumed his role as a psychiatric counselor for Weller's team, for a time.
Mary Stuart Masterson as Eleanor Hirst (seasons 2–5), the second director of the FBI in the series and Pellington's successor. Though she at first formed a friendship with Jane, Weller, and the team and helped take down Sandstorm at the end of season 2 (and even attended Jane and Weller's wedding), she was eventually revealed to be corrupt in season 3 after killing fellow agent Stuart to cover up her connections to corrupt business magnate Hank Crawford. After an attempt to frame the team for her crimes, she was ultimately exposed and arrested. Following her arrest, she reappears on two separate occasions, being questioned by the team about her ties to the tattoos, and later as a hallucination resulting from Jane's ZIP poisoning in the series finale.
Amy Margaret Wilson as Briana Ross (seasons 2–5), an FBI analyst who frequently works with Weller's team. She idolizes them. Near the end of season 4, she is forced to betray the team to protect her parents, when Dominic Masters, the Burke's right-hand man, blackmails her. In season 5, she is recruited by Director Matthew Weitz and fellow analyst Afreen Iqbal to help bring Madeline Burke down, but Madeline soon murders her in cold blood as a warning to discourage any further attempts to cross her. She later reappears as a hallucination caused by Jane's ZIP poisoning in the series finale.
Ami Sheth as Afreen Iqbal (seasons 3–5), an FBI analyst who frequently works with Weller's team. In season 5, after Madeline Burke frames the team and takes over the FBI, she works with Director Matthew Weitz and fellow analyst Briana Ross in a secret alliance against Madeline. The alliance falters for a while after Madeline murders Briana, but the two are eventually able to find and erase all of Madeline's blackmail material, which later proves useful when her crimes are finally exposed to the public.
Heather Burns as Kathy Gustafson (seasons 3–5), a hacker who previously worked with Patterson and Rich during the time between seasons 2 and 3 as the trio known as the "Three Blind Mice". At first, she tries to force the trio back together to avenge her brother, but she fails and is imprisoned. In season 4, she is paroled, and soon gets engaged to Madeline Burke's right-hand man, Dominic Masters, who uses her to execute Project: Helios. She later returns in the penultimate episode of the series and helps the team stop Madeline and Dabbur Zhan's master plan. She appears as a hallucination due to Jane's ZIP poisoning in the series finale.
Jordan Johnson-Hinds as Stuart (seasons 3–5), a young, tech-savvy agent who replaces Patterson after she leaves the FBI between seasons 2 and 3. He remains with the team following her return in season 3, but he is soon murdered by Director Eleanor Hirst after he unwittingly unearths a connection between her and one of Jane's new tattoos. He reappears in flashbacks in season 4 and as a hallucination as a result of Jane's ZIP poisoning in the series finale.
Tori Anderson as Blake Crawford (seasons 3–5), a wealthy socialite, daughter of Hank Crawford, whom Roman befriends and with whom he becomes romantically involved. At the end of season 3, she fatally shoots Roman after learning his true identity from Zapata and inherits her father's company HCI Global after his death. However, at the start of season 4, she is fatally poisoned by Madeline Burke, one of the company shareholders, along with the rest of the company's board. She later reappears as a hallucination as a result of Jane's ZIP poisoning in the series finale, where she and Roman are married.
Kristina Reyes as Avery Drabkin (seasons 3 & 5), Jane's daughter, the result of a teenage pregnancy, who was taken from her by Shepherd in order to keep Remi focused on Sandstorm and their mission. After assisting the team in taking down Crawford – who was responsible for the death of her adopted father – she leaves for Brown University between seasons 3 and 4. She returns in the series finale, having dinner with her mother and many family and friends.
David Morse as Hank Crawford (seasons 3 & 5), Blake Crawford's father, a powerful businessman and CEO of HCI Global, head of a criminal conspiracy. He plans to take control of various significant military resources so that he can set himself up as a new dictator. Jane kills him at the end of season 3. He reappears as a hallucination as a result of Jane's ZIP poisoning in the series finale.
Bill Nye as a fictional version of himself (seasons 3–5) who is Patterson's father.
Reshma Shetty as Megan Butani (seasons 3 & 5), an investigative journalist and Reade's fiancée. She has lived in the U.S. all her life, but she is technically an illegal immigrant because her parents entered the country illegally when she was an infant. When Reade learns of her situation, he attempts to use his connections to facilitate her becoming a citizen, but they eventually break up near the end of season 3 She concludes that he has unresolved issues regarding his old feelings for Zapata. She also decides to publish her true story so that it will come out on her own terms. She returns in season 5 and, thanks to Patterson and Zapata, she publishes a story filled with evidence that exposes Madeline Burke's numerous crimes to the public.
Chaske Spencer as Dominic Masters (seasons 4–5), Madeline Burke's right-hand man after she takes over HCI Global. He is killed at the end of season 4 by Jane and Weller, just after he puts Madeline's plan, Project: Helios, into effect. He reappears as a hallucination as a result of Jane's ZIP poisoning in the series finale.
Britne Oldford as Claudia Murphy (seasons 4–5), a deep-cover MI6 agent sent undercover to dismantle HCI Global. After meeting and teaming up with Zapata, she fakes her death with Zapata's help to enable her to return to England. She later comes back to New York to meet up with Zapata and give more information, but she is murdered by Madeline Burke's henchmen before the meeting can take place. She reappears as a hallucination as a result of Jane's ZIP poisoning in the series finale.
Raoul Bhaneja as Richard Shirley (seasons 4–5), Madeline Burke's lawyer, who is complicit in her schemes. In late season 5, after Madeline's crimes are exposed and the blackmail material against their connections is lost, he attempts to go to the Dabbur Zhan for help. He is quickly betrayed and killed by Ivy Sands, a member of the terrorist group. He reappears as a hallucination as a result of Jane's ZIP poisoning in the series finale.
David Clayton Rogers as Ice Cream (seasons 4–5), an Icelandic fixer to whom the team turns when they need to hide after being framed as terrorists by Madeline Burke. After the team goes into hiding following the drone strike, he tracks them down and forces them to carry out a heist and pay off their debt. He threatens to sell them out to Madeline. He reappears as a hallucination as a result of Jane's ZIP poisoning in the series finale.
Julee Cerda as Ivy Sands (season 5), a member of the Dabbur Zhan terrorist group and the leader of a team of mercenaries that Madeline hires to track down Weller's team in season 5. Following Madeline's death, Ivy continues to pursue their plan: to detonate ZIP bombs in major cities worldwide. When that fails, she tries to detonate one in Times Square but is foiled and arrested, becoming the last arrest the team makes before they are dismissed from the FBI.
Tracie Thoms as Arla Grigoryan (season 5), interim director of the FBI. Following the deaths of Matthew Weitz and Madeline Burke and the collapse of the latter's new power structure, she is appointed to succeed Madeline, becoming the fourth & final director of the FBI in the series. She allows Weller's team to take the lead on capturing Ivy Sands and stopping her plans. She manages to get them immunity deals for the crimes for which they were framed, but on condition that they not return to the FBI or work for any other government agency.
