Busto is a surname. Notable people with the surname include:
Ernesto Hernández Busto (born 1968), Cuban writer living in Barcelona
Javier Busto (born 1949), Spanish choral music composer and conductor
José Antonio del Busto Duthurburu (1932–2006), Peruvian historian
José María Busto (1923–2012), Spanish footballer
Manu Busto (born 1980), Spanish footballer
Manuel Busto (1932–2017), French former professional racing cyclist
Michael Busto (born 1986), Canadian ice hockey defenceman
Milton Busto (born 1982), Nicaraguan professional midfielder