Political career
Following the Eurozone crisis, Moedas was appointed coordinator of the Social Democratic Party (PSD) Economic Research Unit. He and Eduardo Catroga led PSD negotiations in the run-up to Portugal's 2011 State Budget, following which he was selected by PSD to contest the Beja constituency in the legislative elections held on the 5th of June 2011.
Moedas was elected to Parliament, becoming the first PSD Member of Parliament for that district since 1995. The day after entering Parliament, on 21 June 2011, the Prime Minister appointed him to his Cabinet in the XIX Constitutional Government as Secretary of State.
Moedas oversaw EASME (Executive Agency for Small and Medium-sized Enterprises), the agency created to monitor and control the implementation of the structural reforms agreed in the context of the assistance programme by a troika composed of the European Commission, European Central Bank and the International Monetary Fund.
In 2014, Pedro Passos Coelho, Prime Minister of Portugal, nominated him as European Commissioner, and Moedas' name was approved by EC President-elect Jean-Claude Juncker on 1 September. On 1 November 2014, Moedas became European Commissioner for Research, Science and Innovation.
In March 2021, Moedas announced his candidacy as Mayor of Lisbon in the 2021 local elections, and was elected on 26 September of the same year. He took office on 18 October 2021.