2010s
In the thriller Unthinkable (2010), directed by Gregor Jordan, Moss played the leader of an FBI counter-terrorism team assigned to interrogate a man who threatens to detonate three nuclear bombs in the United States. The film was released direct-to-DVD and generated controversy over its subject matter. She took on the role of antagonist Claudia Wolf in the sequel to the 2006 horror film Silent Hill, Silent Hill: Revelation (2012). Budgeted at US$20 million, the film grossed US$52.3 million worldwide, but garnered an overwhelmingly negative reception among film critics and fans alike. Mentioning Moss in its review for the film, The New York Times remarked that the supporting actors "deserve much, much better". She voiced the character Aria T'Loak in the video games Mass Effect 2 (2010) and Mass Effect 3 (2012).
She had a four-episode arc in the series Chuck between 2011 and 2012, and played the regular role of Las Vegas Assistant District Attorney Katherine O'Connell in the CBS period drama series Vegas, which premiered in September 2012, but was cancelled after its first season, despite an overall positive response. Writing for The New York Times, Mike Hale felt that Moss "feels out of place in this frontier tale, but looks great in snug wool suits". Moss obtained the role of Penelope, a California candidate for governor who runs a free health clinic, in the political thriller Knife Fight (2012), directed by Bill Guttentag. The film premiered at the Tribeca Film Festival and was released for a two-theater run and digital platforms. Moss headlined the psychological dark comedy Compulsion (2013), in which she played one of two people occupying neighbouring apartments, each one grappling with psychological disorders that begin to overtake their lives. The film opened for limited release. She voiced the character of Admiral Wells in the fantasy animated film The Clockwork Girl (2014).
She starred in the 3D historical disaster picture Pompeii (2014), produced and directed by Paul W. S. Anderson. The film, inspired by the eruption of Mount Vesuvius in 79 that destroyed the Roman Empire city Pompeii, had her portray Aurelia, the wife of the city governor. In the independent drama Elephant Song (2014), directed by Charles Binamé, Moss starred as the wife of a psychiatrist. The film was screened at the Toronto International Film Festival, and in its review for the film, Variety described her role as "a pushily self-centered second wife" and found her part to be "a poorly integrated subplot" in the film. In 2015, she voiced a widowed mother in the made-for-television animated film Pirate's Passage, was one of the narrators in the documentary Unity, and appeared as the wife of Victor Frankenstein in Frankenstein, an updated adaptation of Mary Shelley's book.
In 2015, Moss appeared in Jessica Jones as Jeri Hogarth, an attorney and potentially powerful ally to the title character. The gender of the character was changed from male to female for the series, and the character was written as a lesbian. Moss signed on to the series after reading the first two scripts, having been pitched the character by producer Jeph Loeb and screenwriter Melissa Rosenberg. She described the character by saying, "she's fierce, she's strong, she's powerful, and she likes that power". The web series premiered on Netflix, to critical acclaim. Moss has also reprised her role of Jeri Hogarth in the second-season finale of Daredevil, and has had recurring arcs in Iron Fist and The Defenders. Moss took on the lead role of Dr. Athena Morrow, an AI researcher invited to reverse engineer a consciousness program, in the second season of the science-fiction series Humans. Moss filmed a supporting part in the supernatural horror film The Bye Bye Man (2017), playing what Variety described as "the world's most soft-edged hard-bitten police detective". Despite negative reviews, the film grossed US$24 million worldwide on a budget of US$7 million.