Elections
When nine-term incumbent Republican U.S. Congressman Ron Packard did not run for reelection in 2000, in California's 48th congressional district. Issa ran for the seat, capitalizing on his name recognition from the 1998 Senate race. The district was primarily based in northern San Diego County, but had small portions in Riverside and Orange counties. Issa finished first in the all-party primary with 35% of the vote, winning a plurality in all three counties; Republican state senator Bill Morrow was second, with 24% of the votes. Issa won the November general election, defeating Democratic nominee Peter Kouvelis 61%–28%.
After redistricting, Issa's district was renumbered the 49th and lost its share of Orange County. Like its predecessor, the district was still overwhelmingly Republican; it had a Cook Partisan Voting Index (PVI) of R+10. No Democrat filed against Issa that year. He was reelected, defeating Libertarian nominee Karl Dietrich, 77%–22%.
A write-in candidate from the 2002 election, Mike Byron, became the Democratic challenger in 2004. Issa was reelected to a third term, defeating Byron 63%–35%.
Issa was reelected to a fourth term, defeating Democratic nominee Jeeni Criscenzo, 63%–33%. He was one of four Middle Eastern American members in that Congress. He has said that he identified primarily as Lebanese, not as pan-Arab.
Issa was reelected to a fifth term, defeating Democratic nominee Robert Hamilton, 58%–37%. The 21-point margin of victory was the second smallest in Issa's career. He carried San Diego with 60% of the vote and Riverside with 57% of the vote.
Issa was reelected to a sixth term, defeating Democratic nominee Howard Katz, 63%–31%.
After the 2010 census, Issa's district was renumbered the 49th and made significantly more compact. It lost its share of Riverside County, along with most of its share of San Diego County. It gained a small portion of southern Orange County, including San Clemente, San Juan Capistrano, Dana Point, and part of Laguna Niguel. The district was more competitive on paper than its predecessor. The old 49th had a PVI of R+10, while the new 49th has a PVI of R+4.
Issa was reelected to a seventh term, defeating Democratic nominee Jerry Tetalman, 58%–42%. The 16-point margin of victory was the smallest in Issa's political career. Issa carried the San Diego portion of his district with 55% of the vote and the Orange County part with 66%.
The June open primary was contested by Issa and two Democrats: Dave Peiser and Noboru Isaga. The top two vote-getters, Issa (62%) and Peiser (28%), advanced to the general election. Issa was elected to an eighth term, 60% to 40%.
In the June open primary, Issa received 51% of the vote to 46% for Democrat Doug Applegate, a retired Marine colonel. Issa and Applegate advanced to the general election in November. In October, Applegate and Issa were ranked by the Cook Political Report as equally likely to win.
Issa sent out a campaign mailer that featured a photograph of President Barack Obama signing a law. The mailer said that Issa was "very pleased" that Obama signed the Sexual Assault Survivors' Rights Act, which Issa had co-sponsored.
Unusually, President Obama responded to this late campaign mailer by saying that Issa's "primary contribution to the U.S. Congress has been to obstruct and to waste taxpayer dollars on trumped up investigations that have led nowhere." Obama said that, because of fading support for Donald Trump, Issa was promoting his cooperation with the president although he had previously accused Obama of corruption.
Issa said, "I've worked with the administration on good legislation where it was possible, called out wrongdoing wherever I saw it and will continue to do so."
On November 23, 2016, Issa held a 3,234-vote lead with approximately 6,000 ballots still uncounted. He declared victory, but Applegate had not conceded. The Associated Press finally declared Issa the winner on November 28, citing a small but convincing lead with only a few votes left to count.
Multiple Democrats, including Applegate and environmental attorney Mike Levin, launched campaigns for California's 49th district seat. Given the close margin in 2016, the election was expected to be highly competitive. For months, Issa's Vista office was the site of weekly protests. Hundreds of people gathered to protest against Trump and his agenda and actions. At a May rally, 800 people showed up to protest the House vote to repeal and replace the Affordable Care Act (Obamacare). On January 10, 2018, Issa announced that he would not run for reelection. Democrat Mike Levin won the seat.
On September 26, 2019, Issa announced that he was running for California's 50th congressional district in the 2020 election. The incumbent at that time was fellow Republican Duncan D. Hunter, who was then under indictment. In December 2019, Hunter pleaded guilty to campaign finance violations and resigned from Congress effective January 13, 2020, leaving the seat vacant.
In redistricting, the 50th district had absorbed much of Issa's former base in the more Republican inland portion of San Diego County. Issa placed second in the March 3, 2020, blanket primary and beat Democratic challenger Ammar Campa-Najjar by nearly 30,000 votes in the general election. Issa said he could switch districts because he owns his mother's home in Bonsall. He has long lived in Vista, where he has raised his family.