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Season 1

The show follows the lives of surgical interns and resident doctors of Sanjeevani hospital. It deals with the pressures, drama, romance, interpersonal relationships and humour in their lives. At the start of the show, the interns are Dr Anjali Gupta, Dr Armaan Malik, Dr Riddhima Gupta, Dr Atul Joshi, and Dr Sapna Shah. Dr Shashank Gupta is the head of the hospital and the father of Anjali and Riddhima.

Initially, Armaan and Riddhima were at loggerheads. Anjali and Armaan become good friends, and Riddhima, Atul and Sapna become a good friend. A medical camp is arranged in a village where Armaan and Riddhima come closer towards each other, and Armaan begans to fall in love with Riddhima. Slowly, they become friends. Riddhima learns that she is Nurse Padma's daughter and not Dr Shashank's real daughter. Anjali makes a bet with Armaan that Riddhima will fall for him. Riddhima learns about this. She is heartbroken. After few instances, they resolve their differences, and Riddhima finally confesses her love to Armaan. They are enjoying their togetherness.

Two new interns enter Dr Rahul Garewal and Dr Muskaan Chadda. Rahul and Armaan have a tashan between them. Muskaan likes Armaan and Rahul likes Riddhima. Meanwhile, Atul started liking Anjali and Sapna marries a patient. Rahul and Muskaan's family wants them to get married, but they don't want to. To get away from this situation, Muskaan receives help from Armaan without telling Riddhima about this. This leads to a separation between Armaan and Riddhima. Rahul now knows about them.

Nurse Padma and Dr Shashank wed. Dr Shubhanker likes Dr Keerti. Riddhima and Armaan become friends again, and eventually, they confess again, marking their togetherness. On the other side, Muskaan and Rahul develop feelings for each other. Dr Nikita Malhotra joins Sanjeevani. Nikita turns out to be Armaan's and Rahul's college friend secretly in love with Armaan. Dr Abhimanyu Modi enters Sanjeevani to save it from a financial crisis. He makes some decisions that the interns did not accept. They do non-cooperation movement and arrange a special show to collect funding. Dr Abhimanyu develops feelings for Dr Riddhima first. All the friends doubt that Armaan and Riddhima are together. So, they ask Nikita's help. But Nikita helps Armaan instead in keeping the secret, and they all think Armaan and Nikita have a scene instead of Riddhima. Armaan thinks of impressing Dr Shashank, disguising himself and changing his looks into a soft, straightforward person. Riddhima is pissed off because of this. Armaan arranges a particular date for her. Unfortunately, the police catch them, and everyone learns about them. No one allows them to meet each other. Armaan takes help from all their friends to persuade Dr Shashank and Anjali against their relationship. He starts living outside their house in a tent. The media started to publicise this matter. Finally, on Valentine's Day, Dr Shashank gives in due to Ridhhima's deteriorating health and accepts them, "Dr Love" gets his love, and Armaan Riddhima comes together. Their Roka is planned.

Armaan's family comes. Billy is very frank, which Dr Shashank doesn't like. Billy and Annie were separated, and Dr Shashank wants to dig out this matter. Armaan Riddhima started to have differences on this. Dr Keerti and Shubhanker wed. Bubbly, sister of Dr Shubhanker, is frank with Armaan, which Riddhima does not like. Due to Dr Abhimanyu and Bubbly, Armaan Riddhima have constant fights. One day, Armaan had an accident, and he lost his recent memory, including Riddhima. Riddhima is heartbroken. Armaan makes fun of her unknowingly that she is her life, Riddhima. Armaan has to rewrite the medical exam. She helps him. Both come closer. Friends try to tell Armaan how much he loved her. They both are together again. They are about to get engaged. On the day of engagement, a pregnant couple tries to hide in the hospital. Prominent politicians were involved in the case. Armaan and Riddhima are also stuck in the situation. In the last scene of the first season, Riddhima is shot, and she falls over Armaan, who hits a glass table. Atul is also shot. Dr Abhimanyu estranged wife, Jiah, returns.

Recurring

Mohnish Bahl as Dr. Shashank Gupta – Head of Sanjeevani hospital. Father of Anjali and Riddhima. Widower of Smriti; later marries Nurse Padma. (2007-2010)

Pankit Thakker as Dr. Atul Joshi – Dr. Omi's (Sanjeevani Season 1) adoptive son. Eco-friendly and lives with plants. Armaan's best friend and Anjali's love interest. (2007-2010)

Sunaina Gulia as Dr. Anjali Gupta – Riddhima's elder sister. Atul's love interest. (2007-2010) Anjali later appeared in Sanjivani, portrayed by Sayantani Ghosh.

Sonia Singh as Dr. Kirti Mehra Rai – Sanjeevani's senior resident doctor. Sukirti's twin sister. Shubhankar's love interest. Later, Shubhankar's wife. (2007-2010)

Sonia Singh as Sukirti Mehra- Kirti's twin sister.

Ayaz Khan as Dr. Shubhankar Rai – Sanjeevani's senior resident doctor. Kirti's love interest & later, Kirti's husband, Navneeta's father. (2007-2010)

Mayank Anand as Dr. Rahul Garewal – Intern, Friends with Armaan and Muskaan's love interest. (2007-2009)

Drashti Dhami as Dr Muskaan Chadda – Intern, Rahul's love interest. (2007-2009)

Amit Tandon as Dr. Abhimanyu Modi –Senior doctor in Sanjeevani. Nikita's love interest. (2008-2010)

Shweta Gulati as Dr. Nikita Malhotra – Loved Armaan since college days, but falls in love with Abhimanyu in Sanjeevani. (2008-2010)

Muskaan Mihani as Dr. Sapna Shah – Intern in Sanjeevani. Marries a patient Amit. (2007-2008)

Moulshree Sachdeva as Dr. Tamanna Patil – Siddhant's love interest, but becomes engaged to Aniket. (2009)

Neha Jhulka as Dr. Naina Mehta – Intern, Yuvraj's love interest. (2009-2010)

Sehban Azim as Dr. Yuvraj Oberoi – Intern, Naina's love interest. (2009-2010)

Prasad Barve as Dr. Jitendra Prasad – Also known as JP. Intern in Sanjeevani. Close friends with Jiggy. (2009-2010)

Shilpa Tulaskar as Padma Bansal Gupta – Head nurse in Sanjeevani, Riddhima's real mother and Shashank's second wife. (2007-2008)

Ekta Sohini as Padma Bansal Gupta. (2009-2010)

Preeti Amin as Dr. Jiah Modi – Abhimanyu's first wife. A patient with mental illness who tries to separate Nikki and Abhimanyu. (2009)

Karan Paranjpe as Jignesh 'Jiggy – Naina's friend and later, male nurse in Sanjeevani. Also, close friends with JP. (2009-2010)

Madhura Naik as Dr. Suvarna Modi – Siddhant and Abhimanyu's sister. Intern at Sanjeevani. (2010)

Barun Sobti as Dr. Raj Singh – A drug addict patient involved in a love triangle with Naina and Yuvraj. Later, intern at Sanjeevani. (2010)

Vinita Malik as Nani – Smriti's (Shashank's first wife in Sanjivani) mother. Riddhima and Anjali's grandmother. (2007-2009)

Mahesh Jadhav as Nana – Patient who gives valuable life lessons to Armaan and tries to bring Riddhima and Armaan together. Harbours a crush on Dr. Kirti. (2007-2010)

Swini Khara as Minnie – Patient in Sanjeevani. Armaan's mini 'girlfriend'. (2007/2009)

Aasif Sheikh as Balvinder "Billy" Mallik – Armaan's father, Ananya's husband. (2009-2010)

Meher Acharia Dar as Ananya "Annie" Mallik – Armaan's mother, Billy's wife. (2009)

Hemali Karpe as Lovely – Nurse at Sanjeevani. (2007-2010)

Iravati Harshe as Dr. Smriti Gupta – Anjali's mother, Riddhima's adopted mother and Dr. Shashank's late wife. (2007)

Upasana Singh – Abhimanyu, Siddhant and Suvarna's mother. (2010)

Shakti Arora as Sumit – Patient in Sanjeevani and loves Riddhima. (2007)

Deepali Pansare as Sumalatha Dalmiya – Dr. Abhimanyu's assistant. (2009)

Roopal Tyagi as Bubbly/Pari – Shubhankar's sister. (2009)

Kanika Maheshwari as Maya – Armaan's stalker. (2007)

Romanchak Arora as Aniket Joshi – Dr. Tamanna's fiance. (2009)

Jannat Zubair Rahmani as Tamanna – Patient in Sanjeevani. (2010)

Suhail More as Gappu – Patient in Sanjeevani. (2008-2009)

Amey Pandya as Patient in Sanjeevani. (2008)

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