Doc – Nelle tue mani (in English, "Doc – In your hands"), titled Doc in the English translated versions, is an Italian medical drama TV series broadcast on Rai 1 since February 2020, written by Francesco Arlanch and Viola Rispoli.
The series is inspired by the true story of doctor Pierdante Piccioni, former chief of the emergency room of Lodi and Codogno, who forgot the previous 12 years of his life following a car accident in 2013.
The set is the fictional "Policlinico Ambrosiano" hospital of Milan and the plot concerns the doctors working in the internal medicine department.
Season 1 was directed by Jan Maria Michelini and Ciro Visco, while season 2's directors were Beniamino Catena and Giacomo Martelli.
All three seasons aired on Australian TV channel SBS Television's streaming service SBS on Demand, titled Doc.
An American adaptation, Doc, aired on Fox, with Fox Entertainment Studios, Sony Pictures Television and 3 Arts Entertainment producing, starting on January 7, 2025.
A Greek adaptation of the series, with the name Ο Γιατρός (O Giatrós, "The Doc"), was aired on Alpha TV, starting on September 30, 2023 and was ended on May 22, 2026.
A Mexican adaptation of the series, titled Doc, aired on Netflix on 4 March 2026.
An Indian Hindi-language adaptation of the series, titled Hui Gumm Yaadein Ek Doctor, Do Zindagiyaan, aired on Sony SAB on 6 April 2026.
Contents
Plot
Season 1
Professor Andrea Fanti is a well-known and popular doctor working at the Policlinico Ambrosiano hospital of Milan, where he is the chief of the internal medicine department. Despite his achievements, he is undeniably arrogant, narcissistic, and a rigid micromanager. Fanti believes that patients are often dishonest, leading him to handle those in his care with an oppressive and at times harsh approach. He places his trust solely in the carefully chosen members of his team, particularly his assistant, Giulia Giordano, a fellow doctor with whom he maintains a clandestine relationship.
One day, the father of Giovanni Pavesi, a young boy who died in Fanti's ward following a mistake (he was given the wrong medicine due to a homonymy error), waits for Fanti to end his shift at the hospital and shoots him in the head. Though the doctor does not die, he suffers from an irreversible prefrontal trauma, which causes him to forget the previous 12 years. Indeed, when Fanti wakes up from the coma, he believes that it is June 2008 instead of 2020 and his last memory is him coming home after signing his first contract with the Policlinico Ambrosiano. Forgetting most of the staff he used to work with, Fanti becomes a kinder and more thoughtful man instead of the authoritarian doctor he once was.
Thrown into a present he sometimes struggles to understand, obliged to start over most of his life and to deal with relevant trauma like his child's death and the separation from his wife (which he forgot), he perceives his loved ones as strangers. As a consequence, the hospital becomes the only place where Andrea feels really at home and where he can try to build a new private and working future.
No longer able to be the chief of the department of which he used to be in charge, he comes back to work as a "doctor with limitations", that is a kind of assistant for young residents, who nickname him "Doc", and uses empathy to interact with patients and help solve their medical issues. In the meantime, he starts a psychological journey with Sardoni, a longtime friend and colleague of his.
Season 2
Set in an unspecified future, COVID-19 critical stage has ended and the Policlinico Ambrosiano comes back to normal activity.
Several flashbacks allow us to understand what happened during the acute phase of the COVID-19 pandemic in Italy. Many wards were converted to face the emergency, including the internal medicine department. However, the hospital had limited resources and people to cope with thousands of patients in a very short time, so, once the emergency ends, the high number of dead doctors and patients leads to an investigation by both the Italian Magistrates' court and the hospital itself, involving all the medical staff, medical director Agnese Tiberi, Andrea Fanti and his team.
Among the victims of COVID-19, there is Lorenzo Lazzarini, a member of Fanti's team later identified as the patient zero, the one who unintentionally introduced the virus in the Policlinico: only his colleagues know the truth about him being the index case and they keep the secret to honour his memory. However, his death, which occurred under unclear circumstances, is also a matter of investigation.
In the meantime, Agnese is suspended from her role as director due to the investigation about the department he managed during the pandemic and starts working as a senior doctor in the ward she used to belong to, which doctor Sandri manages. The lawyer Caruso, also chief of the administrative department, is appointed as the new medical director with the aim of finding out the truth about how the doctors tackled the pandemic emergency.
At the same time, doctor Cecilia Tedeschi, famous virologist and scholar of infectious diseases, is appointed as chief of the internal medicine department, a vacant role after the imprisonment of professor Sardoni and temporarily held by doctor Giordano during the pandemic. Tedeschi is also a former Agnese and Andrea's university mate and was once in love with Andrea, who did not reciprocate her feelings.
Tedeschi secretly wants to turn the internal medicine department into an infectious diseases department with Caruso's help.
Trying to save his department, keep his team united and protect everyone from the investigation, Andrea decides to get his role as chief of the department back, facing several exams intended to certify his eligibility. While doing so, Andrea also needs to deal with Caruso, who does not want him to manage that department for some unknown reasons.
Season 3
2023. Andrea is back as chief of the internal medicine department and must once again manage its responsibilities, including training new residents. Furthermore, the new administrative director pressures him to reduce the department's costs and increase efficiency. In the meantime, Agnese accepts the role of health director again. While going through a crisis phase with her partner, she often meets with Professor Bramante, her and Andrea's former Medicine teacher, with whom she seems to have a dark secret in common.
In this season, Andrea's memories partially resurface, albeit fragmented and often not authentic, as his unconscious created them. Enrico and Giulia will again be at his side in his quest to reconstruct the events. However, the latter is engaged in scientific research to become the department chief in another hospital.
Cast and characters
Main
Luca Argentero as Dr. Andrea Fanti
Matilde Gioli as Dr. Giulia Giordano
Pierpaolo Spollon as Dr. Riccardo Bonvenga
Raffaele Esposito as Dr. Marco Sardoni (season 1)
Sara Lazzaro as Dr. Agnese Tiberi
Gianmarco Saurino as Dr. Lorenzo Lazzarini (season 1; recurring season 2)
Simona Tabasco as Dr. Elisa Russo
Alberto Malanchino as Dr. Gabriel Kidane
Silvia Mazzieri as Dr. Alba Patrizi (season 1-2)
Beatrice Grannò as Carolina Fanti
Elisa Di Eusanio as Nurse Teresa Maraldi
Giovanni Scifoni as Dr. Enrico Sandri
Alice Arcuri as Dr. Cecilia Tedeschi (season 2-present)
Marco Rossetti as Dr. Damiano Cesconi (season 2-present)
Gaetano Bruno as Dr. Edoardo Valenti (season 2-present)
Laura Cravedi as Dr. Martina Carelli (season 3-present)
Giacomo Giorgio as Dr. Federico Lentini (season 3-present)
Elisa Wong as Dr. Lin Wang (season 3-present)
Recurring
Simone Gandolfo as Davide
Mariarosa Russo as Irene Ceraldo (season 1)
Pia Lanciotti as Dr. Fabrizia Martelli (season 1-2)
Giusy Buscemi as Dr. Lucia Ferrari (season 2)
Massimo Rigo as Umberto Caruso (season 2)
Lorenzo Frediani as Father Massimo (season 2)
Arianna Scommegna as Dr. Marrabini (season 3)
Aurora Peres as Barbara (season 3)
Guest stars
Valeria Fabrizi as Tilde Ravelli
Fiammetta Cicogna as Vittoria
Alberto Molinari as Edoardo Grotti
Ilaria Spada as Serena Ruffo
Giacomo Poretti as Giacomo