Francis Holles, 2nd Baron Holles (1627–1690) was an English noble, and only child of Denzil Holles, 1st Baron Holles (best known as one of the five members of parliament whom King Charles I of England attempted to arrest in 1642) and his first wife Dorothy, daughter and heiress of Sir Francis Ashley. Francis inherited the peerage of Baron Holles from his father.
Francis represented both the Wiltshire and Lostwithiel British parliamentary constituencies. Whilst sitting for the latter, he was excluded from the Pride's Purge, which took place in December 1648. He was also returned for Dorchester in both elections of 1679, in March and October (parliament dissolved 1681).
His son Denzil Holles, 3rd Baron Holles (1675–c. 1692), inherited his title.
A sculpture of Francis by Nicholas Stone exists in Westminster Abbey.