Gayton is a surname, and may refer to:
Albert Gayton (1840–1923), Canadian merchant and politician
Anna Hadwick Gayton (1899–1977), American anthropologist, folklorist and museum curator
Clark Gayton, American musician
Clark Gayton (1712–1785), British Royal Navy Officer
Edmund Gayton (1608–1666), English academic, physician and author
Howard Gayton, a founder of the Ophaboom Theatre Company
Joe Gayton (c. 1956/1957–2023), American writer, director and producer
Tony Gayton, American film producer and screenwriter