Marriages and issue
Villiers married firstly Audrey Saunders (d.1587), the daughter and heir of William Saunders (d. 14 July 1582) of Harrington, Northamptonshire and Frances Zouche, the daughter of William Zouche of Bulwick, Northamptonshire, son of John la Zouche, 7th Baron Zouche (c.1440-1527) of Harringworth, who fought for Richard III at Bosworth, by whom he had two sons and four daughters:
Sir William Villiers (d. 12 June 1629), the eldest son, who married Rebecca Roper, daughter and co-heir of Robert Roper, esquire, and Elizabeth Nott, the daughter of William Nott, esquire, of Thames Ditton. He was created a baronet in 1619.
Sir Edward Villiers, who married, about 1612, Barbara St. John, daughter of Sir John St John of Lydiard Tregoze, Wiltshire, by whom he had ten children.
Elizabeth Villiers (d. 1654), who married John Boteler, 1st Baron Boteler of Brantfield.
Anne Villiers (b. 1588), who married Sir William Washington (1590–1648), elder brother of Lawrence Washington (the great-great-grandfather of George Washington). She was the mother of Henry Washington and the maternal grandmother of George Legge, 1st Baron Dartmouth, ancestor of the Earls of Dartmouth.
Frances Villiers, who died without issue.
Villiers married secondly, about 1590, his "beautiful but penniless first cousin by the half-blood", Mary Beaumont (c. 1570 – 1632), daughter of Anthony Beaumont of Glenfield, Leicestershire, with whom he had three sons and a daughter:
John Villiers, Viscount Purbeck, who married Frances, the daughter of Sir Edward Coke by his second wife, Elizabeth Hatton, née Cecil, daughter of Thomas Cecil, 1st Earl of Exeter. The peerage expired at his death.
George Villiers, 1st Duke of Buckingham, who married Katherine Manners, (daughter of the 6th Earl of Rutland). The title became extinct in 1687.
Christopher Villiers, 1st Earl of Anglesey. The earldom and barony became extinct on the death of his son, the second Earl of Anglesey, in 1661.
Susan Villiers, who married William Feilding, 1st Earl of Denbigh, parents-in-law to James Hamilton, 1st Duke of Hamilton.
