Holton is a surname. Notable people with the surname include:
Brian Holton, baseball player
Cliff Holton, English footballer
David Holton, professor of Modern Greek
DeShaun Holton (1973-2006), musician/rapper
Edward D. Holton, American politician and businessman
Gary Holton, actor and musician
Gary Holton (linguist), American linguist
Gerald Holton, professor of physics
Hart Benton Holton, American politician
Henry Dwight Holton, American physician and politician from Vermont
Jim Holton, football player
Linwood Holton (1923–2021), American politician from Virginia
Luther Hamilton Holton, politician and businessman
Michael Holton (born 1961), American basketball player and coach
Mark Holton, actor
Pat Holton, football player
Paul Holton (born 1993), American racing driver
Richard Holton, British philosopher
Richard H. Holton (1926–2005), American economist
Robert A. Holton (1944–2025), American chemist and academic
Tyler Holton, American baseball player
Woody Holton, historian