Political career
Lourenço's early politics were mainly confined within the MPLA as an officer responsible for keeping guerrilla soldiers' morale high. Following his appointment as Governor of Moxico Province in 1984, he continued to rise through the ranks of the ruling party. He also served as the provincial commissioner of Moxico Province for the MPLA, president of the Regional Military Council of the 3rd Military Political Region, First Secretary of MPLA and Provincial Commissioner of Benguela Province. He was the MPLA's Secretary for Information from 1992 to 1997 and President of the MPLA Parliamentary Group in the National Assembly from 1993 to 1998.
At a party congress, he was elected as Secretary-General of the MPLA on 12 December 1998. His election was said to be linked to the favour of President José Eduardo dos Santos and it was thought that Lourenço could potentially succeed the long-ruling dos Santos at some point. However, after dos Santos said in 2001 that he would not seek re-election as president, Lourenço openly expressed an interest in becoming the MPLA's presidential candidate and thereby damaged his standing with dos Santos, who apparently had no real intention of leaving office, but had sought to expose political rivals. Juilão Mateus Paulo succeeded him as MPLA Secretary-General at a December 2003 party congress.
Lourenço was First Vice-president of the National Assembly from 2003 to 2014. He was appointed as Minister of Defense in April 2014, and he was designated as vice-president of the MPLA in August 2016. In September 2018, he became the Chairman of the MPLA, replacing José Eduardo dos Santos.
Lourenço is very close to Elliott Broidy. Through Broidy's firm Circinus, Broidy allegedly received $6 million in January 2017 for lobbying on behalf of the interests of Angola by arranging meetings with Angolans and several Republican United States Senators including Ron Johnson and Tom Cotton, fostering a closer relationship between Washington, and Luanda, attempting to arrange meetings among Lourenço and Mike Pence and Donald Trump and allowing Lourenço to attend a September 2017 event at Trump's Mar-a-Lago club of which Broidy is a member, however, Lourenço did not attend.