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Joseph D. Mougous

researcher

Joseph D. Mougous

American professor of microbiology and biochemistry

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About Joseph D. Mougous

Joseph Mougous is an American microbiologist. He is the John F. Enders Professor of Microbial Pathogenesis and a Howard Hughes Medical Institute Investigator at Yale University. He previously served as a Professor of Microbiology, the Lynn M. and Michael D. Garvey Endowed Chair in Gastroenterology, the Director of the Microbial Interactions & Microbiome Center, and a Howard Hughes Medical Institute Investigator at the University of Washington. Mougous is best known for contributions to the field interbacterial antagonism, including discovering the antibacterial activity of the Type VI secretion system (T6SS).

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A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus A type VI secretion system of Pseudomonas aeruginosa targets a toxin to bacteria Type VI secretion delivers bacteriolytic effectors to target cells Type VI secretion system effectors: poisons with a purpose MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions Structure and regulation of the type VI secretion system Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors United States

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