Louis-Charles Greffulhe (9 February 1814 – 27 September 1888) was a French count and politician. He was the elder son of Jean-Henry-Louis Greffulhe and his wife, Marie-Françoise-Célestine-Gabrielle de Vintimille du Luc. She was a granddaughter of Charles de Vintimille and the great-great-great-great-granddaughter of adventuress Hortense Mancini.
He served as a member of the French Chamber of Peers from 1839 to 1848. He was a supporter of King Louis-Philippe.
He was married to Félicité-Pauline-Marie de La Rochefoucauld d'Estissac. They had three children, including Henry Greffulhe.