Louis Phélypeaux, Seigneur of La Vrillière (10 April 1599–1681), seigneur de La Vrillière, marquis de Châteauneuf and Tanlay (1678), comte de Saint-Florentin, was a French politician.
He was the son of Raymond Phélypeaux (†1629), seigneur d'Herbault et de La Vrillière. In 1621, he was made a Minister of State and served as Secretary of State for Protestant Affairs from 1629 to 1681. He was also Provost and Master of Ceremonies of the Ordre du Saint-Esprit from 1643 to 1653.
He was the father of Balthazar Phélypeaux (1638–1700) and grandfather of Louis Phélypeaux (1672–1725).
After he died in 1681, he was buried in a baroque tomb in the church of Saint Martial of Châteauneuf-sur-Loire.