Recurring
Tony Plana as Devante Cano (season 1), the Galindo Cartel consejero who loyally served Jose Galindo and mentors his successor Miguel.
Ada Maris as Dita Galindo (seasons 1–2; guest season 3), Miguel's mother and Jose's widow. She also has a history with Felipe Reyes, her former lover.
Gino Vento as Nestor Oceteva, the former head of security for the Galindo Cartel and a childhood friend of Miguel's. He later becomes a prospect, sponsored by Marcus, for the Mayans M.C., Santo Padre Charter.
Joe Ordaz as Paco (seasons 1–2; guest season 3), Miguel's personal driver and a member of the Galindo Cartel.
Maurice Compte as Kevin Jimenez (season 1), a highly regarded DEA agent who makes it his personal mission to take down the Galindo Cartel.
Curtiss Cook as Larry Bowen (season 1), a DEA agent who works with Kevin on taking down the Galindo Cartel.
Salvador Chacón as Pablo (seasons 1–3), the second-in-command of Los Olvidados who serves as Adelita's right-hand man.
Melony Ochoa as Mini (seasons 1–3; guest season 5), also known as "La Ratona" (The Mouse), a child member of Los Olvidados who has a close relationship with Adelita.
Daniel Faraldo as Father Rodrigo (season 1), a Christian priest who preaches in Santo Padre and is an old friend of Felipe. He also has a history with Adelita's father, Pedro Espina.
Alexandra Barreto as Antonia Peña (seasons 1–3), the mayor of Santo Padre and Katrina's wife. She is a former lover of Bishop and the mother of their deceased son, Aidan Losa.
Michael Ornstein as Chuck "Chucky" Marstein (seasons 1–2), reprising his role from Sons of Anarchy, who now works at a junkyard in Santo Padre for the Mayans M.C. He is later stated to have moved to Ohio.
Ada Luz Pla as Celia (season 1; guest season 3), Coco's manipulative mother who works as a prostitute and raised her granddaughter Leticia Cruz as her own.
Emily Tosta as Leticia "Letty" Cruz, Coco's daughter who was raised by her grandmother Celia for most of her life believing she was his younger sister.
Edwin Hodge as Franky Rogan (seasons 1–2; guest season 3), a police officer in the Santo Padre Police Department who is friendly with the Mayans.
Ray McKinnon as Lincoln "Linc" James Potter (seasons 1–2, 5; guest seasons 3–4), reprising his role from Sons of Anarchy as an Assistant U.S. Attorney based in California, now investigating both the Mayans M.C. and Los Olvidados.
David Labrava as Happy Lowman (season 2; guest seasons 1, 3, 5), reprising his role from Sons of Anarchy as the Sargeant-at-Arms of SAMCRO (Sons of Anarchy Motorcycle Club, Redwood Originals), the founding charter of the Sons of Anarchy M.C. He is later revealed to have killed Marisol Reyes as part of a murder-for-hire contract and also killed the eldest son of Marcus Alvarez, Esai Alvarez, during a previous conflict with SAMCRO.
Ivo Nandi as Oscar "El Oso" Ramos (seasons 2–3), reprising his role from Sons of Anarchy as the Presidente of the Mayans M.C., Stockton Charter and one of the three Kings of the Mayans M.C.
Jimmy Gonzales as Canche (seasons 2–4), the Presidente of the Mayans M.C., Yuma Charter and one of the three Kings of the Mayans M.C.
Mía Maestro as Sederica Palomo (seasons 2–3), the governor of Baja California who works with Miguel Galindo in secret.
Efrat Dor as Anna Linares (seasons 2–3; guest season 4), a government agent working with Lincoln Potter in the investigation of the Mayans M.C. and Los Olvidados.
Mikal Vega as Hobart (season 2), a mercenary squad leader hired by Lincoln Potter to destroy Los Olvidados.
Malaya Rivera Drew as Ileana (season 2), an old friend of Emily now working for the Santo Padre city council.
Mike Beltran as Ibarra (season 3; guest season 2), the Presidente of the Mayans M.C., Tucson Charter and a close ally of the Santo Padre charter.
Loki as Lobo (seasons 3–5; guest season 2), the former El Pacificador of the Mayans M.C., Tucson Charter. He later patches over to the Sahuarita Charter and again to the Santo Padre Charter.
Vanessa Giselle as Hope (seasons 3–5; guest season 2), a heroin addict who starts a relationship with Coco and later becomes close friends with Leticia after getting sober. She is also a former member of Isaac's drug community at Meth Mountain.
Michael Anthony Perez as Luis (seasons 3–5; guest season 2), a loyal sicario for the Galindo Cartel and later the LNG Cartel who often acts as extra muscle.
Gregory Cruz as El Palo (season 3; guest season 2), El Unico (The One, aka President) of the Vatos Malditos M.C., who make their money through human trafficking and recruit members without the prospecting process. After the disbandment of his club, he later patches over to the Mayans M.C., Yuma Charter. He is also the brother of Laura.
Momo Rodriguez as Esteban "Steve" Estrada (season 3), a former prospect, sponsored by Hank, and later a full patch member of the Mayans M.C., Santo Padre Charter, who's dreamed of joining a M.C. his whole life.
Justina Adorno as Stephanie (seasons 3–4; guest season 5), more commonly known as "Nails", one of the bartenders at the clubhouse of the Mayans M.C., Santo Padre Charter who has a recurring fling with Angel.
Grace Rizzo as Jess (seasons 3–5), one of the bartenders at the clubhouse of the Mayans M.C., Santo Padre Charter who spies on the Mayans for SAMDINO. She is also Jazmine's sister.
Holland Roden as Erin Thomas (season 3; guest season 4), Emily Galindo's younger sister, who moves to Santo Padre to live with her and reconnect.
Patricia de Leon as Izzy Alvarez (seasons 3–5), the wife of Marcus Alvarez who lives in Santo Padre with him and her step-children.
Spenser Granese as Butterfly (season 3; guest season 5), a drug dealer and member of Isaac's drug community at Meth Mountain.
Natalia Cordova-Buckley as Laura (season 3), El Palo's sister, who is distant from him for killing their brother.
Greg Vrotsos as Terry Drakos (seasons 4–5; guest season 3), the Vice President of SAMDINO who seeks to start a war with the Mayans.
Guillermo García as Ignacio (season 4; guest season 3), more commonly known as "El Banquero" (The Banker), the unstable leader of the Lobos Nueva Generación Cartel (LNG), a radical criminal organization made up of the remnants of the Lobos Sonora Cartel, who were previously defeated by the Galindo Cartel under Jose Galindo. He is also the brother of Soledad.
Augie Duke as Treenie Gaeta (seasons 4–5; guest season 3), the wife of Tommy Gaeta who later becomes a bartender at the clubhouse of the Mayans M.C., Santo Padre Charter and has a casual relationship with Bishop.
Manny Montana as Manny (season 4), an up-and-coming full patch member and later Vice Presidente of the Mayans M.C., Yuma Charter who befriends EZ and shares his ideals for the future of the Mayans.
Angel Oquendo as Downer (seasons 4–5), a full patch member of the Mayans M.C., Yuma Charter who values loyalty to the club above all else. He later patches over to the Santo Padre Charter.
Andrea Cortés as Sofia (seasons 4–5), an employee at an animal shelter who helps EZ adopt a dog, Sally, and later starts a relationship with him. In a previous relationship, she had a young daughter whose death she unintentionally caused.
Stella Maeve as Katie McNeill (seasons 4–5), also known by the undercover alias "Kody", an ex-junkie who befriends Creeper at an NA meeting as part of a ruse whilst working as an undercover ATF agent.
Greg Serano as Jay-Jay (season 4), an ex-convict who EZ was associated with whilst in prison.
Selene Luna as Soledad (seasons 4–5), the calculative leader of Lobos Nueva Generación Cartel and El Banquero's sister who seeks to regain her organization's former glory and take control of the drug trade.
Erica Luttrell as Rae (seasons 4–5), Gilly's former commanding officer in the U.S. Army Rangers, Paul's wife, and the mother of their son.
Presciliana Esparolini as Maggie (season 5; guest season 4), Izzy's friend who is set up with Bishop.
Andrew Jacobs as Guero (season 5), a full patch member of the Mayans M.C., Santo Padre Charter after patching over from the disbanded Tucson Charter where his father Ibarra was Presidente.
Alex Barone as Bottles (season 5), a newly recruited prospect for the Mayans M.C., Santo Padre Charter.
Caitlin Stasey as Johnny Panic (season 5), the President of the Broken Saints M.C., an all-female club which is in conflict with the Iron War M.C.
Lauren McKnight as Chip (season 5), the Vice President of the Broken Saints M.C.
Dana Delany as Patricia Devlin (season 5), the Deputy Assistant Inspector General of the Division of Investigations who investigates Lincoln Potter.
Luis Fernandez-Gil as Elio (season 5), an experienced meth cook working for the LNG Cartel, who is kidnapped and forced to work for the Mayans.
