Mikołaj Sapieha (Lithuanian: Mykalojus Sapiega) (1581–1644) also known as Pobożny ("Pious") was a Polish–Lithuanian nobleman and Grand Lithuanian Standard-Keeper. He was also Voivode of Minsk, Voivode of Brześć Litewski and Castellan of Vilnius.
In 1638 he became Voivode of Minsk (from July), before taking the post of Voivode of Brześć Litewski in November that year. In 1642 he became the Castellan of Vilnius.