Mühlen is a German surname. Notable people with the surname include:
Ernest Mühlen (1926–2014), Luxembourgish politician
Georg Mühlen-Schulte (1882–1981), German writer
Heribert Mühlen (1927–2006), German theologian
Hermynia Zur Mühlen (1883–1951), Austrian writer and translator
Kurt von Mühlen (1905–1971), German military officer
Louis Muhlen-Schulte (born 1998), Australian alpine skier
Raimund von zur-Mühlen (1854–1931), German tenor
Tomo in der Mühlen, German musician