Rhino Entertainment released the first two seasons on Region 1 DVD in 2004–2005. Rhino never released the third season. However, the season 3 release from Australia's Umbrella Entertainment, on February 5, 2008, was as an import to North America. This release is classified as "Region 0", making it viewable around the world on any region-free DVD player. Rhino also released a three-DVD box of "The Best of My Favorite Martian" in 2007, comprising episodes 1, 2, 3, 5, 7, 9, 14, 16, 18, 22, 24, 29, 31, 34, and 37.
In January 2010, MPI Home Video acquired the series' Region 1 rights under license from the Jack Chertok estate-owned Jack Chertok Productions. At the time, it was announced that they planned on releasing season 3 on DVD in the summer of 2010. This release, however, never materialized and was postponed. It was subsequently released on October 30, 2012.
MPI re-released season 1 on June 24, 2014. and season 2 on December 23, 2014. They would go on to release the complete series on October 20, 2015.
In Region 4 (Australia), Umbrella Entertainment released all three seasons on DVD. These releases are all region free. The season 1 release includes special features, such as audio commentary with Ann Marshall, a stills gallery, script, and interview with Ann Marshall. The season 3 release also includes special features, such as an unaired version of the series pilot, behind the scenes home movies, interviews with Stan Frazen, Ted Rich, James Hulsey, and Wayne Stam, as well as audio commentary by James's Hulsey and Chertok historian and licensing manager Peter Greenwood. In addition, there are also scans of the original comic series, scripts, and the shooting schedule.