Palacios is a Spanish surname meaning palace. It is the plural form of the habitational surname Palacio. Notable people with the name include:
Abel Iturralde Palacios (1869–1935), Foreign Minister of Bolivia
Adrián Palacios (born 2004), Venezuelan footballer
Alfredo Palacios (1880–1965), Argentine politician
Antonia Palacios (1904–2001), Venezuelan writer
Antonio Palacios (1874–1945), Spanish architect
Antonio Palacios Lanza (born 1952), Venezuelan chess master
Antonio José Martínez Palacios (1902–1936), Spanish composer
Arnold Palacios (1955–2025), 10th Governor of the Northern Mariana Islands.
Augusto Pérez Palacios (1909–2002), Mexican architect
Bárbara Palacios (born 1963), Venezuelan entrepreneur, Miss Universe 1986
César Palacios (born 2004), Spanish footballer
Claudia Palacios (born 1977), Colombian journalist and newscaster
Eloy Palacios (1847–1919), Venezuelan sculptor
Emilio Palacios (born 1982), Nicaraguan footballer
Ernesto Palacios de la Prida (1943–2000), Spanish chess master
Exequiel Palacios (born 1998), Argentine footballer
Felipa Palacios (born 1975), Colombian track and field athlete
Fermín Palacios, 19th-century president of El Salvador
Helibelton Palacios (born 1993), Colombian footballer
Isabel Palacios (born 1950), Venezuelan musician and wife of José Ignacio Cabrujas
Isabel Palacios (scientist), winner of a 2019 Suffrage Science award
Josh Palacios (born 1995), American baseball player
Juan Palacios (disambiguation)
Juan Palacios (basketball) (born 1985), Colombian basketball player
Juan Palacios (boxer) (born 1980), Nicaraguan boxer
Juan Palacios (cyclist) (born 1962), Ecuadorian cyclist
Juan José Palacios (1944–2002), Spanish musician and record producer
Karen Palacios, Venezuelan clarinetist
Lucila Palacios (1902–1994), Venezuelan poet
Luis Esteban Palacios, Venezuelan Chairman of the Inter-American Scout Committee
Marco Antonio Palacios (born 1981), Mexican football player, also known as Pikolin
Marcos Palacios (fl. 2000s–2010s), American music producer
Miguel Asín Palacios (1871–1944), Spanish scholar and Roman Catholic priest who published Islam and the Divine Comedy in 1919
Monica Palacios (playwright), Chicana lesbian American playwright and performer
Mónica Palacios (politician), Ecuadorian politician
Nicolás Palacios (1854–1931), Chilean physician and writer, best known for his racial ideas
Odón Betanzos Palacios (1925–2007), Spanish writer
Rafael Palacios (priest) (died 1979), Roman Catholic El Salvadoran priest
Rafael Palacios (artist) (1905–1993), Puerto Rican-American artist and map-drawer
Raimundo Andueza Palacios, a 19th-century president of Venezuela
Rey Palacios (born 1962), American former baseball player
Richie Palacios (born 1997), American baseball player
Roberto Palacios (born 1972), Peruvian football player
Santiago Palacios (born 1991), Mexican football (soccer) player
Sebastián Palacios (born 1992), Argentine footballer
Sheynnis Palacios (born 2000), Nicaraguan model, beauty pageant titleholder and Miss Universe 2023 titleholder
Steve Palacios (born 1993), American soccer player
Tatiana (singer) (born 1968), Mexican singer and actress known as Tatiana
Tiago Palacios (born 2001), footballer, born in Argentina, he represents Uruguay at international level
Tomás Palacios (born 2003), Argentine footballer
Victoria Palacios (born 1977), Mexican race walker
Wilson Palacios (born 1984), Honduran football player