Alfredo Perl (born 1965), Chilean-German pianist and conductor
Arnold Perl, American dramatist
Curdin Perl, Swiss cross-country skier
Edward Perl (1926–2014), American neuroscientist
Gisella Perl (1907–1988), Jewish Holocaust survivor and author
Günter Perl, German football referee
Gyula Pál, born Gyula Perl, Hungarian-Danish mathematician
Hille Perl (born 1965), German musician (viola da gamba, lirone)
Wubong (1950–2013), born Jacob Perl, Polish Zen master
Jed Perl (born 1951), American art critic and writer
Josef Perl (1930–2018), Holocaust survivor and educator
Joseph Perl, German-Jewish writer and religious commentator
Karl Perl, Austrian sculptor and engraver
Martin Lewis Perl (1927–2014), American physicist and Nobel Prize laureate
Rafał Perl (born 1981), Polish diplomat
Reto Perl, Swiss ice hockey player
Sasha Perl-Raver, American writer and actress
Sondra Perl, American academic
Teri Perl, American mathematics educator
William Perl, American physicist and Soviet spy
Zoltán Perl, Hungarian basketball player