In 1974, Frampton appeared in the film The Son of Dracula as a guitarist in the Count Downes.
In 1978, Frampton portrayed coastwatcher Peter Buckley in an episode of the World War II drama series Baa Baa Black Sheep titled "A Little Bit of England".
In 1978, Frampton played Billy Shears in the film Sgt. Pepper's Lonely Hearts Club Band, starring along with the three brothers Gibb of the band the Bee Gees. The film was inspired by the Beatles album of the same name. Critics were hostile, and the film was a box-office failure.
In 1978, Frampton appeared on the parody talk show, America 2-Night.
In 1988, Frampton appeared in the video release of David Bowie's Glass Spider, a video recording of the 1987 tour of the same name.
In 1996, Frampton appeared in an episode of The Simpsons entitled "Homerpalooza", in which he played "Do You Feel Like We Do". He also made a TV appearance in the Family Guy episode "Death Lives", in which Peter Griffin asks Death to bring Peter Frampton to play "Baby, I Love Your Way" to Lois.
Also in 2000, Frampton served as a technical advisor for Cameron Crowe's autobiographical film, Almost Famous. He wrote some of the songs performed by the fictional band "Stillwater" in the film, supplied guitar tracks, and was the guitar instructor for Billy Crudup, who starred as Russell Hammond, the guitarist for the band. Crudup is quoted as saying, "Who could ask for a better tutor than Peter Frampton?" As an inside joke, he also appears briefly in the film as "Reg", a road manager for Humble Pie, Frampton's real-life former band.
In 2001, Frampton appeared as himself in "Drew Carey's Back-to-School Rock 'n' Roll Comedy Hour", in which he performed "You Had To Be There" and appeared in a brief scene with Mimi, in which he recalls their past relationship.
On 20 December 2006, Frampton appeared on The Colbert Report. Stephen Colbert had a fake feud with the Decemberists to be decided by a head cutting duel. When Colbert faked an injury, Colbert called on Father Christmas to supply a guitar hero, at which point Frampton appeared and won the shred-down.
On 23 April 2010, Frampton became the all-time celebrity champion of the trivia game called No Apparent Reason, with five correctly answered questions on the nationally syndicated Mark and Brian Radio Program originating from KLOS Los Angeles. However, on 5 May 2010, Frampton was reduced to second place after only two weeks by Luke Perry's answering six questions correctly.
On 4 November 2010, Frampton appeared on The Oprah Winfrey Show as one of her favourite musicians.
On 21 October 2011, Frampton was honoured at Music City's at Walk of Fame Park in Nashville, Tennessee.
On 2 March 2016, Frampton was interviewed and performed on the Howard Stern Show.
On 17 March 2016 Frampton performed a NPR Music Tiny Desk Concert with guitarist Gordon Kennedy. The performance was published on 27 April 2016 on the NPR Music YouTube channel.
On 6 January 2019, Frampton appeared as himself on Madam Secretary, where he performed a small portion of "Baby I Love Your Way". He similarly appeared on the final episode of that program (aired 7 December 2019) performing numerous songs at the wedding of the President's daughter.
On 6 August 2021, Frampton challenged OJ Borg through his Radio 2 game "Mid-Afternoon Mastermind" (as Borg was covering for Steve Wright's afternoon show). The subject was Peter Frampton, and Borg scored 2/3.
In January 2024, Frampton played guitar alongside Sheryl Crow for her induction into the Rock & Roll Hall of Fame, with her and Stevie Nicks singing "Every Day is a Winding Road".
In a 31 January 2024 airing of the Fox game show We Are Family, Frampton's son Julian appeared as a relative of an unknown mystery celebrity. After a solo performance of "Rebel Rebel", he then sang a duet of "Black Hole Sun" with the concealed mystery celebrity. At the conclusion of the segment, Peter Frampton was revealed as the other half of the duet.
On March 17, 2026, Frampton announced a new album to be released in May 2026, titled Carry the Light. Produced with his son Julian, it would be his first album of new material in 16 years. The album includes guest appearances by Sheryl Crow, Graham Nash, and Benmont Tench. One of the tracks, "Buried Treasure", is a tribute to Tom Petty.
