Additional cast
David Wilmot as Sergeant Donald Artherton (series 1–3), the long-standing desk sergeant of H Division who is forced to retire after contracting a serious case of gout
David Dawson as Fred Best (series 1–3; guest series 5), editor of the local newspaper, who often irritates the men of H Division by imposing on ongoing investigations in the hope of obtaining a story
Clive Russell as Detective Chief Inspector Frederick Abberline (series 1–3, 5), former commander of H Division and lead investigator in the Ripper murder case. Abberline and Reid have a somewhat on/off relationship, often differing in opinion on methods of investigation.
Jonathan Barnwell as Police Constable Dick Hobbs, a junior constable assigned to H Division who is murdered in the line of duty by a serial offender whilst trying to protect a woman from being abducted
Lucy Cohu as Deborah Goren (series 1 and 4), head of the Jewish orphanage, who becomes involved with Edmund Reid in the first series after she offers him hope of finding his missing daughter
Amanda Hale as Emily Reid, Edmund Reid's wife. Their marriage is strained by the disappearance and presumed death of Mathilda, something which Emily blames her husband for, choosing to neglect her marriage in favour of charitable works. She is incarcerated in a mental institution between series 1 and 2, where she dies between series 2 and series 3.
Gillian Saker as Bella Drake (series 1 and 2), a prostitute working for Long Susan, and later Bennet Drake's wife, who dies after being brainwashed by a cult which she was involved in several years previously, which saw her bear a child to the cult leader
Ian McElhinney as Theodore P. Swift (series 1 and 3), Long Susan's father, who is the owner proprietor of a U.S. bank that falls into heavy debt, resulting in his need to flee the country and protect all of his remaining wealth in unregistered bearer bonds
Damien Molony as Detective Constable Albert Flight, a junior constable just out of uniform who is assigned to H Division by Chief Inspector Abberline
Joseph Mawle as Detective Inspector Jedediah Shine (series 2 and 5), the feared inspector of K Division whom Reid tries to unveil as the man responsible for a string of untimely murders. Shine later returns in the fifth series to take up the position of Inspector of H division.
Leanne Best as Jane Cobden (series 2 and 3), a local councillor who first comes to prominence as the opposing candidate for Walter De Souza, who is abducted in the line of duty for his part in the match girls' strike of 1888
Alicia Gerrard as Charity (series 2 and 3), a prostitute working for Long Susan, who later goes on to become receptionist at the clinic following the closure of the brothel
Frank Harper as Silas Duggan, property owner and barber who owns the building in which Long Susan operates her brothel
John Heffernan as Ronald Capshaw, Long Susan's solicitor, who persuades her to rob one of her father's cargo trains
Louise Brealey as Dr Amelia Frayn, senior physician at the clinic opened by Long Susan following the closure of her brothel. Frayn also cares for Mathilda Reid in the early days after her release from captivity.
Lydia Wilson as Hermione "Mimi" Morton (series 3 and 5), Homer Jackson's girlfriend. Mimi is sister to Edgar Morton, Rose Erskine's fiancé and employer.
Josh O'Connor as Police Constable Bobby Grace, junior constable in H Division
Anna Burnett as Mathilda Reid (series 3–5), Reid's long lost daughter with whom he is reunited after she is discovered to have been held captive since her disappearance some six years previously in the SS Princess Alice disaster on the Thames
Killian Scott as Assistant Commissioner Augustus Dove, a senior officer at Scotland Yard. Dove is known to have participated in corrupt activity, predominately associated with his long-lost brother, Nathaniel.
Matthew Lewis as Sergeant/Inspector Samuel "Drum" Drummond, desk sergeant of H division who replaces the outgoing Sergeant Atherton
Benjamin O'Mahony as Detective Sergeant / Sergeant Frank Thatcher, Drake's right-hand-man
Anna Koval as Rachel Castello, a local reporter who takes over as editor of the Star newspaper
Jonas Armstrong as Nathaniel Croker, also known as Nathaniel Dove, Abel Croker's assistant and Augustus Dove's brother
Kahl and Kye Murphy as Connor Judge, Homer Jackson and Long Susan's son, who is born during her years of incarceration
