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Sam Hay

chemist

Sam Hay

New Zealand chemist

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About Sam Hay

Sam Hay is a chemist from New Zealand and a Professor of Biophysical Chemistry in the Department of Chemistry and Manchester Institute of Biotechnology (MIB) at The University of Manchester. His research in general is based on computational chemistry and theoretical chemistry, specifically on the areas of In silico Enzymology, quantum mechanics roles in biological processes, kinetic modelling of complex reactions and high pressure spectroscopy.

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Occupation: chemist, university teacher

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Good vibrations in enzyme-catalysed reactions Reductive dehalogenase structure suggests a mechanism for B12-dependent dehalogenation New cofactor supports α,β-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition.UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis Fast protein motions are coupled to enzyme H-transfer reactions Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effects Direct analysis of donor-acceptor distance and relationship to isotope effects and the force constant for barrier compression in enzymatic H-tunneling reactions University of Manchester Stockholm University

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