Career
In 2005, he began performing regularly at The Comedy Store in West Hollywood, California. Maniscalco cites Jerry Seinfeld, George Carlin, Brian Regan, John Ritter, Johnny Carson, Andrew Dice Clay, Bill Burr, and Don Rickles as comedic influences. Since then, he has done a half-hour for Comedy Central Presents and five hour-long specials. His first special, Sebastian Live, was released on June 2, 2009. His next three specials were aired on Showtime, with What's Wrong with People? released on January 5, 2012, Aren't You Embarrassed?, taped in Chicago, released on November 14, 2014, and Why Would You Do That?, taped in New York City and released in 2016.
Maniscalco was one of four comedians featured in Vince Vaughn's Wild West Comedy Show: 30 Days & 30 Nights – Hollywood to the Heartland, along with Ahmed Ahmed, John Caparulo, and Bret Ernst. Maniscalco has been on Russell Peters' Best Night Ever, Comedy Central Presents, The Late Late Show with Craig Ferguson, The Tonight Show with Jay Leno, The Jay Leno Show, The Tonight Show Starring Jimmy Fallon, Conan, and The Late Show with Stephen Colbert. Additionally, he appeared in several films, such as The Nut Job 2: Nutty by Nature, The House, Tag, and Cruise, and he co-hosts a podcast titled The Pete and Sebastian Show with fellow comedian Pete Correale. As of January 2017, they have a show on Sirius XM satellite radio's Raw Dog Comedy channel 99. Maniscalco appeared on the seventh season of Comedians in Cars Getting Coffee in 2016 and returned to the series in 2019 for its eleventh season. He published his memoir Stay Hungry on February 27, 2018. A Netflix special also titled Stay Hungry was released on January 15, 2019.
In 2017, Maniscalco made his feature film debut in The House, and the following year he appeared as Johnny Venere in the Academy Award-winning film Green Book. Maniscalco hosted the 2019 MTV Video Music Awards on August 26. In November 2019, Maniscalco appeared in Martin Scorsese's The Irishman playing "Crazy" Joe Gallo alongside Robert De Niro, Joe Pesci, and Al Pacino. He also hosted the three-part companion podcast for the film, first published on December 2, 2019, titled Behind the Irishman.
In June 2021, it was announced that Maniscalco will host a reality television show titled Well Done With Sebastian Maniscalco that premiered on August 12, 2021, on Discovery+ where he will be joined by friends and family to explore food culture and etiquette. Four days after the premiere, the show was renewed for a six-episode second season that premiered on November 16, 2021. In August 2021, during a podcast, he announced that he was a part of the cast of Illumination's The Super Mario Bros. Movie, playing the role of Spike from the game Wrecking Crew as Mario and Luigi's boss.
Maniscalco's 5th comedy special, Is It Me?, was released on December 6, 2022, on Netflix. On May 26, 2023, About My Father was released in theaters, a comedy film Maniscalco co-wrote loosely based on his life and in which he co-starred with Robert De Niro, who played the role of his father. Maniscalco starred for two seasons in the television series Bookie, which debuted on November 30, 2023.
On April 23, 2025, it was announced that Maniscalco would appear in an Apple's first ever scripted podcast, titled Easy Money: The Charles Ponzi Story. Maniscalco will voice Charles Ponzi and the podcast is said to discuss the rise and fall of Ponzi as well as his schemes. The podcast will be hosted by Maya Lau.
In September 2025, Maniscalco participated in the Riyadh Comedy Festival. Joey Shea, Saudi Arabia researcher at Human Rights Watch, said in a statement that the Saudi government is using the comedy festival to whitewash its human rights abuses.
In 2026, SiriusXM launched Sebastian Maniscalco's Comedy Radio, taking over channel 99. A new show, The Sebastian Maniscaclo Show, will replace the previous The Pete and Sebastian Show.