2010s
In early 2010, Gisondo had a recurring role in the detective comedy-drama series Psych portraying a young version of James Roday's character Shawn Spencer, replacing Liam James. In 2011, Gisondo acted as Billy and voiced B-Dawg in the supernatural comedy film Spooky Buddies, the fifth installment in the Air Buddies series, winning the Best Performance in a DVD Film - Young Ensemble Cast shared with Tucker Albrizzi, Sierra McCormick, Jake Johnson and Sage Ryan at the 33rd Young Artist Awards.
In 2012, Gisondo had a voice role in the comedy film Treasure Buddies, the sixth installment in the Air Buddies franchise. On the same year, he played the young version of Chris Diamantopoulos' character Moe Howard in the comedy movie The Three Stooges directed by Peter Farrelly and Bobby Farrelly. Gisondo played the role of Howard Stacy in the 2012 American superhero film by Marc Webb titled The Amazing Spider-Man. In 2014, he reprised his role in the film's sequel The Amazing Spider-Man 2 starring Andrew Garfield, Emma Stone and Jamie Foxx. Gisondo was cast in the 2014 fantasy comedy film by Shawn Levy's titled Night at the Museum: Secret of the Tomb starring Ben Stiller, Robin Williams, Owen Wilson, Rami Malek, Dan Stevens and Ben Kingsley, in which he played the role of Nicholas "Nick" Daley. His character was played by Jake Cherry in the previous films.
In 2015, Gisondo starred in the road comedy movie Vacation opposite Ed Helms, Christina Applegate and Steele Stebbins, which was released on July 29. In 2016, Gisondo starred along with Katrina Bowden and Kristin Chenoweth in the comedy-drama movie Hard Sell written and directed by Sean Nalaboff, which was released on May 20.
In 2017, Gisondo starred alongside Olivia Holt, Kristin Chenoweth, Kathleen Chalfant, Nick Krause, and Peter Maloney in the romantic comedy film Class Rank as Bernard Flannigan, which premiered at the Newport Beach Film Festival on April 21 and had a limited release by Cinedigm on May 11, 2018. In the same year, he appeared in the satirical comedy miniseries Wet Hot American Summer: Ten Years Later.
From 2017 to 2019, Gisondo was cast to play a main role in the comedy horror series Santa Clarita Diet opposite Drew Barrymore, Timothy Olyphant and Liv Hewson, in which he played the role of Eric Bemis.
In 2018, Gisondo co-starred opposite Asa Butterfield and Sophie Turner in the sci-fi comedy drama movie Time Freak, which was released in limited release and on digital on November 9. He starred with Madison Iseman in the comedy movie Feast of the Seven Fishes, which premiered on November 1, 2018 in Fairmont, West Virginia and was released on November 15, 2019.
In 2019, Gisondo was cast as Gideon Gemstone in the comedy crime series The Righteous Gemstones. That same year, he appeared in Olivia Wilde's Booksmart starring Beanie Feldstein and Kaitlyn Dever, playing Jared. He starred opposite Alex Wolff, Mike Epps, Tommy Nelson and Stefania LaVie Owen in the coming-of-age drama film The Cat and the Moon portraying Seamus.
