Acting
In 1994, Izzard's West End drama debut as the lead in the world premiere of David Mamet's The Cryptogram with Lindsay Duncan, in the production at London's Comedy Theatre. The success of that role led to a second starring role, in David Beaird's black comedy 900 Oneonta. In 1995, she portrayed the title character in Christopher Marlowe's Edward II.
In 1998, Izzard appeared briefly on stage with Monty Python in The American Film Institute's Tribute to Monty Python (also referred to as Monty Python Live at Aspen). As part of an inside joke, she walked on stage with the five surviving Pythons and was summarily escorted off by Eric Idle and Michael Palin when attempting to participate in a discussion about how the group got together. In July 2014, she appeared on stage with Monty Python during their live show Monty Python Live (Mostly) as the special guest in their "Blackmail" sketch.
Izzard portrayed comedian Lenny Bruce in the 1999 production of Julian Barry's 1971 play Lenny. In 2001, she replaced Clive Owen in Peter Nichols' 1967 play A Day in the Death of Joe Egg at the Comedy Theatre. Izzard and Victoria Hamilton repeated their lead roles when the show was brought to Broadway in 2003 in the Roundabout Theatre Company production. The revival received four Tony Award nominations, including Best Revival of a Play, Best Leading Actor and Best Leading Actress for its stars Izzard and Hamilton in their Broadway debuts, and Best Direction for Laurence Boswell. In June 2010, she replaced James Spader in the role of Jack Lawson in David Mamet's play Race on Broadway.
Izzard has appeared in numerous films, starting with The Secret Agent in 1996, and has appeared as several real-life individuals, including Charlie Chaplin in The Cat's Meow, actor Gustav von Wangenheim in Shadow of the Vampire, General Erich Fellgiebel in Valkyrie and wartime pioneer of radar Robert Watson-Watt in the BBC drama film Castles in the Sky. Other roles have included Mr Kite in Across the Universe, Lussurioso in Revengers Tragedy and criminal expert Roman Nagel in Ocean's Twelve and Ocean's Thirteen. Her voice work has included the titular "It" in Five Children and It, Nigel in The Wild and the mouse warrior Reepicheep in The Chronicles of Narnia: Prince Caspian. Izzard declined to reprise the role as Reepicheep, a role understudied by Simon Pegg in The Chronicles of Narnia: The Voyage of the Dawn Treader. Izzard has stated that she felt she learned to act while working on the film Circus.
In 2009, Izzard was the subject of Sarah Townsend's documentary Believe: The Eddie Izzard Story, which addresses BBC's Watchdog reporting of "recycling material from an old tour".
Izzard appeared in the 2009 BBC science fiction miniseries The Day of the Triffids, based on the 1951 novel, alongside Jason Priestley, Vanessa Redgrave, Joely Richardson, Dougray Scott and Brian Cox. She played Dr. Hatteras, a sceptical psychology professor, in the Showtime series United States of Tara and appeared in six episodes of the 2013–15 American psychological horror television series Hannibal as Dr. Abel Gideon. In 2021, she appeared in the television series The Lost Symbol based on Dan Brown's 2009 novel of the same name.
At the London 2012 Paralympic Games, Izzard presented the medals to the athletes who had won the 800m T54 race, including gold medalist David Weir.
She has appeared on a number of episodes of BBC One's Have I Got News for You and as a guest on The Daily Show. In 2017, she read excerpts from her autobiography Believe Me for BBC Radio 4's Book of the Week.
From 25 January to 3 March 2024, Izzard performed a one-person version of Shakespeare's Hamlet, adapted by her brother Mark and directed by Selina Cadell, at the Greenwich House Theater in New York. The run was extended three times. The show transferred to Riverside Studios, London, with previews from 23 May 2024.