Voyage
On 10 April, Andrews boarded the ship, having left his room at the South Western Hotel. Immediately upon boarding, he began a thorough inspection. He was pleased with what he found, it was said. Titanic began her maiden voyage from Southampton. Before departure, Andrews took the opportunity to say goodbye to Thomas Hamilton and others who were not accompanying the ship on the voyage. His spirits were high and he said, "Remember now and keep Mrs Andrews informed of any news of the vessel". When the ship nearly collided with the liner SS City of New York, Andrews thought that the situation was "decidedly unpleasant".
A few hours later, the Titanic called at Cherbourg Harbour in north-western France, and Andrews wrote to his wife, "We reached here in nice time and took on board quite a number of passengers...the weather is fine and everything shaping for a good voyage." After departing Queenstown (now Cobh) in Ireland, Andrews, at a dining table, mentioned that in certain ways, the ship was not ready to sail but they had to proceed because the prescheduled sailing date of April 10 arrived and the ship simply had to sail on time. On April 11, Third Class Steward John E. Hart recalled that at some point during the day, there was a general bulkhead inspection. He saw Andrews and Chief Officer Henry Tingle Wilde checking to make sure that the crew would close the watertight doors manually. Andrews' bedroom steward, Henry Etches, noticed that Andrews "was working all the time" taking notes on various improvements he felt were needed, primarily cosmetic changes to various facilities. Jessop said that Andrews "never failed to stop for a cheerful word, his only regret that we were "getting further from home"."
On the night of April 12, stewardess Mary Sloan conversed with Andrews in the Grand Staircase and noted Dr William Francis Norman O'Loughlin note Andrews seemed "loth to go, he wanted to talk about home; he was telling me his father was ill and Mrs Andrews was not so well...he said...he did not like (that the ship) was taking us further away from home...his face struck me as having a very sad expression". However, on the night of 14 April, Sloan felt Andrews was in "good spirits". Eleanor Cassebeer put on a stunning gown and arrived at the Purser's table, which she shared with Dr O'Loughlin and Andrews, a chipper Andrews let out a friendly little cheer for her choice, then he leaned over to her and said, "Now that's the way a lady should look!" Albert Dick and his wife Vera had grown attached to Andrews and noticed that "upon every occasion, and especially at dinner on Sunday evening, he talked almost constantly about his wife, little girl, mother and family, as well as of his home". After dinner, Andrews made his way aft "to thank the baker for some special bread he had made for him" and returned to his stateroom to make calculations and drawings for future use. Andrews reportedly remarked to a friend that Titanic was "as nearly perfect as human brains can make her."