2000s–present: China-Hong Kong co-productions
Tsui returned to directing at home in 2000 after not having made a local film since 1996. Time and Tide (2000) and The Legend of Zu (2001) were action extravaganzas with lavish computer-generated imagery that gained cult admirers but no mass success.
Tsui continues to push technical boundaries and revise old favourites. Old Master Q 2001 was Hong Kong's first combination of live action and Pixar-style 3D computer animation. The Era of Vampires (2002; US title, "Tsui Hark's Vampire Hunters") reworked a subgenre popular in the '80s, hybrid martial arts / supernatural horror films featuring the "hopping corpses" of Chinese folk legend. He also directed a short film in 2003, titled Believe It or Not, which was part of the 1:99 Shorts, featuring 11 segments of short films made by various directors and featured many Hong Kong actors to raise awareness against the 2002–2004 SARS outbreak. The following year Tsui also produced a martial arts filmed named Xanda.
In 2005, Tsui launched the multimedia production Seven Swords, a film adaptation of Liang Yusheng's novels Saiwai Qixia Zhuan and Qijian Xia Tianshan. The film came with a television series counterpart (Seven Swordsmen), a comic book series, a cellphone game, clothing brand, and an online multi-player video game. The film was relatively successful, and in February 2006 Tsui announced plans to begin filming the second late in the year. As of 2008, Tsui continues to work on the script for Seven Swords 2 in between filming projects. In 2011 there has been no news nor plans about a Seven Swords 2. Rumors has it that due to lack of interest by the filmmakers of finishing the hexalogy lead the project into being cancelled.
In August 2008, Tsui provided art direction for the direct-to-video anime feature titled Kungfu Master (a.k.a. Wong Fei Hong vs Kungfu Panda), an apparent unofficial sequel to Kung Fu Panda, featuring Chinese folk hero Wong Fei-hung. He also directed the 2008 thriller Missing starring Angelica Lee and the 2008 romantic comedy film All About Women featuring comic graphics and extensive ADR dubbing.
Tsui's latest work in 2010 is Detective Dee and the Mystery of the Phantom Flame, a rare but successful blend of wuxia, suspense-thriller, mystery, and comedy, which was in competition for the Golden Lion award and was also nominated and won numerous other awards.
In 2010, he announced his first 3-D film, The Flying Swords of Dragon Gate, which is a re-imagining of his 1992 film New Dragon Gate Inn starring Tony Leung Ka-Fai, Maggie Cheung and Brigitte Lin. In 2011, Huayi Brothers announced that Tsui will be making a prequel to Detective Dee and the Mystery of the Phantom Flame; shot in 3-D, it was released in 2013 as Young Detective Dee: Rise of the Sea Dragon.
In October 2011, Tsui received the Asian Filmmaker of the Year Award at the 16th Busan International Film Festival for his contributions to Hong Kong cinema. He is the fifth Chinese filmmaker to receive this award at Busan.
His film The Taking of Tiger Mountain premiered in China in December 2014.
Tsui worked on a film with Milkyway Image alongside Ann Hui, Ringo Lam, Patrick Tam, Johnnie To, Sammo Hung and Yuen Woo-Ping. Each director created a segment based on Hong Kong history. The completed film, Septet: The Story of Hong Kong, was shown at the Busan International Film Festival on 21 October 2020 and at the annual Hong Kong International Film Festival in April 2021.
In 2021, Tsui co-directed The Battle at Lake Changjin with Chen Kaige and Dante Lam. The film is the most expensive film ever produced in China, the highest-grossing Chinese film of all time, and the highest-grossing non-English film.