Cast
Kelly Clarkson as Moxy, a pink UglyDoll with lots of confidence, hope, and curiosity. Her design is based on that of Gorgeous, a character from the original toyline. She hopes to one day, be loved by a child, and never gives up.
Janelle Monáe as Mandy, a kindhearted perfect doll who wears glasses for eyesight problems and befriends the Ugly Dolls. Mandy also encourages Moxy to not give up, even after the whole town is devastated.
Blake Shelton as Ox, a green UglyDoll with a X eye and the Unofficial Mayor of Uglyville, mentor to all of the other Ugly Dolls and former friend of Lou. He attempts to hide the concept of "children" and “the big world” from the UglyDolls, but fails when Moxy discovers it with her friends.
Wanda Sykes as Wage, an orange UglyDoll and cynical baker who can be frequently found cooking up some amazing and inventive culinary concoctions. She tries to not come with Moxy to the "big world", as she claims she has better things to do, but is convinced. She reveals she thinks Moxy is brave, and she is too scared to go.
Gabriel Iglesias as Babo, a grey UglyDoll and the largest of the UglyDolls who holds lots of items in his pocket.
Wang Leehom as Lucky Bat, a red bat-like UglyDoll who is the thoughtful but shy adviser, who fails at his mission of telling Moxy that the "big world" does not exist, and accidentally encourages her that it does.
Bebe Rexha as Tuesday, a blue-haired perfect doll and one of the Spy Girls
Charli XCX as Kitty, a pink-haired perfect doll and one of the Spy Girls
Lizzo as Lydia, a purple-haired perfect doll and one of the Spy Girls
Nick Jonas as Lou, the preppy prototype leader from the town of Perfection and a bully towards the Ugly Dolls and the other imperfect dolls, wanting everyone who gets a child to be perfect.
Pitbull as Ugly Dog, a one-eyed blue dog-like UglyDoll and Moxy's closest friend.
Pitbull reprises his role in the Spanish dub.
Ice-T as Peggy, a small one-eyed pegacorn
Emma Roberts as Wedgehead, a yellow UglyDoll and the newest citizen of Uglyville
Kelly Asbury as the following roles before his death in 2020:
Gibberish Cat, a cat-like UglyDoll whose name is self-explanatory.
Oliver, an insect-like UglyDoll who admits that he gets greedy with soup.
A large chef UglyDoll that serves soup during Uglyville's time of despair
Buttons, Moxy's printer
Jane Lynch as the scanner that decides the role of the Institute of Perfection's new arrivals with many of them being part models
Natalie Martinez as Meghan, a lawyer and model at the Institute of Perfection
Stephen Zimpel as Michael, an engineer and model at the Institute of Perfection
Enrique Santos as Nolan, a doll at the Institute of Perfection who Lou calls ugly, and was born yesterday. Starts the song “The Ugly Truth”, after asking about Lou.
Rob Riggle as the Exposition Robots who oversee the exams at the Institute of Perfection
Steven Schweickart as a new arrival to Uglyville during its despair
Afi Ekulona as Tray, a three-eyed purple UglyDoll wearing three-eyed glasses who has three brains
Jacques Colimon as Sporko, a spork-shaped UglyDoll
