Wisner is a surname. Notable people with the surname include:
Frank Wisner (1910–1965), American civil servant and father of Frank G. Wisner
Frank G. Wisner (1938–2025), American diplomat and son of Frank Wisner
Henry Wisner (c. 1720–1790), American politician
Moses Wisner (1815–1863), American politician
Quintrevion Wisner (born 2005), American football player