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AstraZeneca Breast Cancer Trial Misses Key Goal
x/pfizer
— 6d
AstraZeneca’s breast cancer pill camizestrant (Etcamah) failed to improve progression-free survival in a late-stage trial when added to standard therapy, despite an earlier ESR1 mutation–targeted approval and after-hours stock weakness. The broader trial that reached more patients failed, while a separate study in ESR1-mutant patients showed a meaningful benefit, underscoring a split outcome for the drug’s potential.
+7
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Marcus Bell
It's frustrating the overall trial missed but good the ESR1 group still saw real benefit from the drug.
Experimental pancreatic cancer drug now available in Nebraska
x/ben-sasse
— Jul 23, 2026
Daraxonrasib, an investigational KRAS-targeting drug, has shown the potential to more than double survival in stage IV pancreatic cancer compared with chemotherapy and is being offered through expanded access programs at Nebraska Medicine, with Ben Sasse publicly discussing his positive response. The FDA has accepted an NDA for daraxonrasib based on phase 3 trial results showing significant improvements in overall survival, progression-free survival, and response rate, signaling a possible breakthrough though not yet FDA approved.
+4
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Hamas To Release Last Living American Hostage
x/israeli
— May 12, 2025
Hamas is set to release the last surviving American hostage in its custody despite slow progress on a potential second ceasefire agreement with Israel, Reuters reported Monday. Edan Alexander, an Israeli-American…
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Nadler in Fight for Survival After Court Upends Democrat Plan to Steal House Seats
Opinion
— May 19, 2022
This is going to be pure, progressive pain — and no one deserves it more. After New York state Democrats tried to gerrymander their way into one-party dominance with cheating so flagrant even a Democrat-dominated court…
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IJR
Gas Industry Says Heating Costs Will Fall 14% This Winter As Another Forecast Warns Of An Increase
Simon August · 6 min · 12h
AstraZeneca Ends Phase III Lung Cancer Trial
x/astrazeneca
— Aug 17, 2026
AstraZeneca reports a setback as its Phase III trial of volrustomig plus chemotherapy in PD-L1 negative metastatic non-small cell lung cancer is halted after an independent data review found it unlikely to meet primary endpoints, while another late-stage study in cervical cancer and other indications continues. In a positive contrast, AZN and partners SAFFRON showed that Tagrisso combined with Orpathys significantly improved progression-free and overall survival, underscoring a mixed near-term outlook but ongoing strength in its immuno-oncology pipeline.
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Most Influential Women in World History
From ancient queens who ruled empires to modern activists who changed laws, these women left indelible marks on politics, science, and culture. Vote for who you think shaped history most profoundly.
1379 votes · 26 candidates
