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EXCLUSIVE: Trump’s Broad Ban On Risky Gain-Of-Function Research Nears Completion

by Daily Caller News Foundation
April 17, 2025 at 5:19 pm
in News, Wire
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EXCLUSIVE: Trump’s Broad Ban On Risky Gain-Of-Function Research Nears Completion
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Daily Caller News Foundation

President Donald Trump could sign a sweeping executive order banning gain-of-function research — research that makes viruses more dangerous in the lab — as soon as May 6, according to a source who has worked with the National Security Council on the issue.

The executive order will take a broad strokes approach, banning research amplifying the infectivity or pathogenicity of any virulent and replicable pathogen, according to the source, who requested anonymity to speak candidly about the anticipated executive action. But significant unresolved issues remain, according to the source, including whether violators will be subject to criminal penalties as bioweaponeers.

The executive order is being steered by Gerald Parker, head of the White House Office of Pandemic Preparedness and Response Policy, which has been incorporated into the NSC. Parker did not respond to requests for comment.

In the process of drafting the executive order, Parker has frozen out the federal agencies that have for years championed gain-of-function research and staved off regulation — chiefly Anthony Fauci’s former institute, the National Institute of Allergy and Infectious Diseases at the National Institutes of Health.

The latest policy guidance on gain-of-function research, unveiled under the Biden administration in 2024, was previously expected to go into effect May 6. According to a March 25 letter cosigned by the American Society for Microbiology, the Association for Biosafety and Biosecurity International, and Council on Governmental Relations, organizations that conduct pathogen research have not received direction from the NIH on that guidance — suggesting the executive order would supersede the May 6 deadline.

The 2024 guidance altered the scope of experiments subject to more rigorous review, but charged researchers, universities and funding agencies like NIH with its implementation, which critics say disincentivizes reporting. Many scientists say that researchers and NIH should not be the primary entities conducting cost–benefit analyses of pandemic virus studies. 

Parker previously served as the head of the National Science Advisory Board for Biosecurity (NSABB), a group of outside experts that advises NIH on biosecurity matters, and in that role recommended that Congress stand up a new government agency to advise on gain-of-function research. Former Centers for Disease Control and Prevention Director Robert Redfield has also endorsed moving gain-of-function research decision making out of the NIH to an independent commission.

“Given the well documented lapses in the NIH review process, policymakers should … remove final approval of any gain-of function research grants from NIH,” Redfield said in a February op-ed.

It remains to be seen whether the executive order will articulate carveouts for gain-of-function research without risks of harm such as research on non-replicative pseudoviruses, which can be used to study viral evolution without generating pandemic viruses.

It also remains to be seen whether the executive order will define “gain-of-function research” tightly enough to stand up to legal scrutiny should a violator be charged with a crime.

Risky research on coronaviruses funded by the NIH at the Wuhan Institute of Virology through the U.S. nonprofit EcoHealth Alliance typifies the loopholes in NIH’s existing regulatory framework, some biosecurity experts say.

Documents obtained through the Freedom of Information Act in 2023 indicated that EcoHealth Alliance President Peter Daszak submitted a proposal to the Pentagon in 2018 called “DEFUSE” describing gain-of-function experiments on viruses similar to SARS-CoV-2 but downplayed to his intended funder the fact that many of the tests would occur in Wuhan, China.

Daszak and EcoHealth were both debarred from federal funding in January 2025 but have faced no criminal charges.

“I don’t know that criminal penalties are necessary. But we do need more sticks in biosafety as well as carrots,” said a biosecurity expert who requested anonymity to avoid retribution from his employer for weighing in on the expected policy. “For instance, biosafety should be a part of tenure review and whether you get funding for future work.”

Some experts say that it is likely that the COVID-19 crisis was a lab-generated pandemic, and that without major policy changes it might not be the last one.

“Gain-of-function research on potential pandemic pathogens caused the COVID-19 pandemic, killing 20 million and costing $25 trillion,” said Richard Ebright, a Rutgers University microbiologist and longtime critic of high-risk virology, to the Daily Caller News Foundation. “If not stopped, gain-of-function research on potential pandemic pathogens likely will cause future lab-generated pandemics.”

All content created by the Daily Caller News Foundation, an independent and nonpartisan newswire service, is available without charge to any legitimate news publisher that can provide a large audience. All republished articles must include our logo, our reporter’s byline and their DCNF affiliation. For any questions about our guidelines or partnering with us, please contact licensing@dailycallernewsfoundation.org.

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