Nagasaki (written: 長崎) is a Japanese surname. Notable people with the surname include:
Hiroko Nagasaki (長崎 宏子; born 1968), Japanese swimmer
Kenji Nagasaki (長崎健司), Japanese director
Kento Nagasaki (長崎 健人; born 1990), Japanese footballer
Kotaro Nagasaki (長崎 幸太郎; born 1968), Japanese politician
Miyu Nagasaki (長﨑美柚; born 2002), Japanese table tennis player.
Shunichi Nagasaki (長崎 俊一; born 1956), Japanese film director and screenwriter
Takashi Nagasaki (長崎 尚志; born 1956), Japanese author, manga writer and former editor of manga
Fictional characters
Soyo Nagasaki (長崎 そよ), a character in the media franchise BanG Dream!