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Genentech-DualityBio Global ADC Deal Over $1B
Business
— 5d
DualityBio and Genentech (Roche) have launched a global collaboration to develop next-generation antibody-drug conjugates using the DUPAC payload platform, featuring a $45 million upfront and potential milestones exceeding $1 billion, with DualityBio leading early discovery and Genentech obtaining exclusive worldwide rights after Phase 1a. The program targets tumors resistant to current topoisomerase-inhibitor–based ADCs, backed by preclinical data and potential expansion into China via the Dupac platform.
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Hanmi Genentech obesity drug deal worth $2.3B reported
x/genentech
— Aug 24, 2026
Hanmi Pharmaceutical has signed an exclusive, worldwide license with Genentech for HM17321, a long-acting UCN2 analog aimed at obesity that promises weight loss with muscle preservation, with Genentech taking over development from Phase 2 onward outside Korea. The deal could reach about $2.3 billion, including a $190 million upfront, up to $2.1 billion in milestones, and future royalties, subject to U.S. antitrust clearance and successful clinical progression.
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BioNTech halts Phase 2 cancer vaccine trial
Health
— 4d
BioNTech and Genentech/Roche have terminated the Phase 2 trial of autogene cevumeran for ctDNA-positive, surgically resected high-risk colorectal cancer after an independent DSMB cited a numerical survival imbalance, with further continuation deemed unlikely to change outcomes. The company will analyze the data to refine patient selection, and a separate Phase 2 trial in pancreatic cancer remains ongoing.
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Video
— YouTube
Driver blows by a stopped school bus while a police officer is behind it
WVLT News · 815.8K views · Aug 31, 2026
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