Blood Marker May Aid Diagnosis of Advanced CTE

5 sourcesUpdated Nov 14, 20261 min read

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Researchers at Washington University School of Medicine identified the blood protein fragment eMTBR-tau243 as a possible marker of advanced chronic traumatic encephalopathy (CTE), a brain disease linked to repeated head injuries that currently can be definitively diagnosed only after death. In a small study using stored blood from 11 people with autopsy-confirmed CTE, levels were higher in advanced disease and distinguished those patients from healthy people, but the marker did not reliably detect early CTE. Because eMTBR-tau243 is also elevated in Alzheimer’s and other tau-related brain disorders, it cannot diagnose CTE on its own, and researchers say the finding is preliminary and has not been validated. Larger studies are needed to determine whether the marker could help assess people at risk or support future research and treatment trials.

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