Hayden Panettiere Died From Fentanyl and Other Drugs, Coroner Rules

By Sandra Rhodes (/journals/sandra-rhodes)

A toxic mixture of fentanyl, 4-ANPP, alprazolam, methocarbamol and quetiapine caused the death of actress Hayden Panettiere, according to the Greenville County Coroner's Office.

The manner of death for Panettiere, 36, was ruled an accident.

"On August 16, 2026, at approximately 1:51 PM, a 911 call was received regarding a reported cardiac arrest at 701 Easley Bridge Road in Greenville," the Greenville County Coroner's Office said in a release obtained by Fox News Digital. "First responders and Emergency Medical Services arrived on scene and located a female in cardiac arrest. EMS personnel initiated advanced cardiac life support measures; however, resuscitation efforts were unsuccessful, and the individual was pronounced deceased at 2:32 PM."

"The Greenville County Coroner’s Office responded to the scene and initiated a parallel investigation with the Greenville City Police Department. The decedent has been identified as Hayden Leslie Panettiere, 36, of California. Panettiere was found unresponsive inside the residence, where she had been temporarily staying.

"An autopsy was completed by a Board Certified Forensic Pathologist. At autopsy no signs of trauma were discovered that would have contributed to the death."

"The cause of death has been ruled as toxic effects of fentanyl, 4-ANPP, Alprazolam, Methocarbamol, and Quetiapine. The manner of death has been ruled accident."

Panettiere was found dead in a Greenville residence on Aug. 16.

Panettiere's boyfriend, Brian Hickerson, and his brother, Zach, called 911 after finding the actress unresponsive, according to a police report obtained by Fox News Digital. Hickerson gave authorities a bag containing medication Panettiere had been taking, according to the report.