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John Vane

biochemist

John Vane

Farmacólogo inglés (1927-2004)

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About John Vane

Sir John Robert Vane fue un farmacólogo británico que fue instrumental en la comprensión de cómo la aspirina produce efectos de alivio del dolor y antiinflamatorios y su trabajo condujo a nuevos tratamientos para la enfermedad del corazón y los vasos sanguíneos y la introducción de inhibidores de la ECA. Fue galardonado con el Premio Nobel en Fisiología o Medicina en 1982 junto con Sune Bergström y Bengt Samuelsson por "sus descubrimientos sobre prostaglandinas y sustancias biológicamente activas relacionadas".

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Occupation: biochemist, pharmacologist, university teacher
Citizenship: United Kingdom
Born: March 29, 1927
Died: November 19, 2004

Facts from Wikidata (CC0). Image by Unknown authorUnknown author via Wikimedia Commons (CC BY 4.0).

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Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation Cyclooxygenases 1 and 2 Regulatory functions of the vascular endothelium Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis?Queen Mary University of London University of London

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